Bioorganic and Medicinal Chemistry Letters p. 1721 - 1726 (1999)
Update date:2022-07-30
Topics:
Kozikowski, Alan P.
Araldi, Gian Luca
Tueckmantel, Werner
Pshenichkin, Sergey
Surina, Elena
Wroblewski, Jarda T.
The synthesis of the 1-amino derivative of (2R,4R)-4-aminopyrrolidine- 2,4-dicarboxylic acid (1-amino-APDC), a selective metabotropic glutamate ligand, is disclosed. This compound acts as a partial agonist of the group II mGluRs and shows pronounced neuroprotective properties in the NMDA model of cell toxicity.
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