23877-94-3

Usage

Uses

Used in Pharmaceutical Industry:
AKOS 92897 is used as an antibacterial agent for treating bacterial infections due to its ability to inhibit bacterial growth and proliferation.
AKOS 92897 is used as a diuretic for promoting increased urine production and excretion, which aids in managing conditions like edema and high blood pressure.
AKOS 92897 is used as an antihypertensive medication for reducing blood pressure by decreasing the reabsorption of sodium and water in the kidneys.
Used in Ophthalmology:
AKOS 92897 is used in the treatment of glaucoma for lowering intraocular pressure, which helps prevent optic nerve damage and vision loss.
Used in Neurology:
AKOS 92897 is used in the management of certain seizure disorders to control and prevent seizures by stabilizing neuronal activity.

InChI:InChI=1/C10H8N2O2/c1-7-5-6-8-9(11-7)3-2-4-10(8)12(13)14/h2-6H,1H3

Upstream product

• 655-76-5 2-Methyl-chinoliniumhydrogensulfat 
• 91-63-4 2-methylquinoline 
• 119689-64-4 2-methylquinoline nitrate 

Downstream Products

• 1027402-28-3 (E)-5-nitro-2-styrylquinoline 
• 54408-50-3 2-methyl-5-aminoquinoline 
• 607-72-7 5-hydroxy-2-methylquinoline 
• 108825-11-2 2-methyl-1,2,3,4-tetrahydro-5-quinolinol 
• 54408-52-5 5-bromo-2-methylquinoline 
• 79205-04-2 5-methoxy-2-methylquinoline 

Relevant academic research and scientific papers

Approach to the synthesis of 8-nitroquinoline-2-carboxylic acid in high yield

A synthesis of 8-nitroquinoline-2-carboxylic acid was optimized, using the following basic scheme of transformations: 1) nitration of 2-methylquinoline with subsequent separation of a mixture of isomeric 8-nitroand 5-nitro-2-methylquinolines; 2) oxidation of the methyl group in 2-methyl-8-nitroquinoline (including consecutive steps of bromination and hydrolysis in aqueous sulfuric acid). A new method for the separation of isomeric 8-nitroand 5-nitro-2methylquinolines was suggested. The optimal conditions for the final step of hydrolysis were selected, which gave almost quantitative yield of 8-nitroquinoline-2-carboxylic acid.

Substitution effect on the one- and two-photon sensitivity of DMAQ "caging" groups

The systematic SAR study of a "caging" group showed a strong influence of the position of the donor dimethylamino group on the efficiency of photolysis of the DMAQ (2-hydroxymethylene-(N,N-dimethylamino)quinoline) caged acetate under one-photon near-UV or two-photon near-IR excitation. Photorelease of l-glutamate by the most efficient 8-DMAQ derivative strongly and efficiently activated glutamate receptors, generating large, fast rising responses similar to those elicited by glutamate photoreleased from the widely used MNI-caged glutamate.

5-SUBSTITUTED QUINOLINE AND ISOQUINOLINE DERIVATIVES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS ANTIPHLOGISTICS

The invention relates to compounds of general formulas (IIa) or (IIb) and to their use as medicaments.

Syntheses of Novel Quinolone-Chemotherapeutics, I: Pyridoquinolines and Pyridophenanthrolines as Derivatives of "lin-benzo-Nalidixic Acid"

Expansion of nalidixic acid (NA) has been accomplished by linear insertion of a benzo-ring between the two pyrido moieties.The resulting compounds exhibit antibacterial activity comparable to NA and are highly fluorescent.The regioselective hydrogenation of 1,7-phenanthrolines was studied. - Keywords: lin-Benzo-analogs; Quinolones; Pyridoquinoline; Pyridophenanthroline; Pyridophenanthroline; Regioselective hydrogenation of phenanthrolines; Fluorescence