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Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
2-Methyl-5-hydroxyquinoline is used as a building block in the synthesis of pharmaceuticals and agrochemicals. Its chemical structure allows for the creation of a variety of compounds with potential therapeutic and pesticidal properties, contributing to the development of new drugs and crop protection agents.
Used as a Corrosion Inhibitor:
In the industrial sector, 2-Methyl-5-hydroxyquinoline serves as a corrosion inhibitor. Its ability to form protective films on metal surfaces helps prevent corrosion, making it a valuable additive in various industrial applications where metal protection is crucial.
Used as a Fluorescent Dye:
2-Methyl-5-hydroxyquinoline also finds use as a fluorescent dye due to its optical properties. It can be employed in various analytical techniques that require fluorescence, such as fluorescence microscopy and spectroscopy, for detecting and analyzing substances.
Used in Antioxidant and Anti-inflammatory Research:
2-Methyl-5-hydroxyquinoline has been studied for its potential antioxidant and anti-inflammatory properties. Its ability to neutralize free radicals and reduce inflammation may make it a promising candidate for use in the development of treatments for various diseases and conditions where oxidative stress and inflammation play a role.

Upstream product

• 54408-50-3 2-methyl-5-aminoquinoline 
• 123-73-9 trans-Crotonaldehyde 
• 367521-07-1 2,4-dibromo-5-hydroxyaniline 
• 23877-94-3 2-methyl-5-nitroquinoline 
• 844903-57-7 5-hydroxy-2-methylquinolinium bromide 
• 123-73-9 crotonaldehyde 
• 27463-92-9 5,6,7,8-Tetrahydro-2-methylquinolin-5-one 
• 91-63-4 2-methylquinoline 
• 1780-19-4 1,2,3,4-tetrahydro-2-methylquinoline 

Downstream Products

• 108825-11-2 2-methyl-1,2,3,4-tetrahydro-5-quinolinol 
• 583031-15-6 2-methyl-5-(2-piperazin-1-ylethoxy)quinoline 
• 149312-98-1 5-hydroxyquinoline-2-carboxylic acid 

Relevant academic research and scientific papers

Multi-Functional Oxidase Activity of CYP102A1 (P450BM3) in the Oxidation of Quinolines and Tetrahydroquinolines

Tetrahydroquinoline, quinoline, and dihydroquinolinone are common core motifs in drug molecules. Screening of a 48-variant library of the cytochrome P450 enzyme CYP102A1 (P450BM3), followed by targeted mutagenesis based on mutation-selectivity correlations from initial hits, has enabled the hydroxylation of substituted tetrahydroquinolines, quinolines, and 3,4-dihydro-2-quinolinones at most positions around the two rings in good to high yields at synthetically relevant scales (1.5 g L?1 day?1). Other oxidase activities, such as C?C bond desaturation, aromatization, and C?C bond formation, were also observed. The enzyme variants, with mutations at the key active site residues S72, A82, F87, I263, E267, A328, and A330, provide direct and sustainable routes to oxy-functionalized derivatives of these building block molecules for synthesis and drug discovery.

Substituted tetrahydro-quinoline-sulfonamide compounds, their preparation and use as medicaments

The present invention refers to substituted tetrahydro-quinoline-sulfonamide compounds of general formula (I): a method for their preparation, a medicament comprising these compounds and the use of substituted tetrahydro-quinoline-sulfonamide compounds for the preparation of medicaments for 5-HT6 receptor regulation as well as for the treatment of disorders related thereto.

SUBSTITUTED TETRAHYDRO-QUINOLINE-SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS

The present invention refers to substituted tetrahydro-quinoline-sulfonamide compounds of general formula (I): a method for their preparation, a medicament comprising these compounds and the use of substituted tetrahydro-quinoline-sulfonamide compounds for the preparation of medicaments for 5-HT6 receptor regulation as well as for the treatment of disorders related thereto.

Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists

5-HT1 receptor antagonists have been discovered with good selectivity over the 5-HT transporter. This is the first report of highly potent, selective ligands for the 5-HT1A/B/D receptors with low intrinsic activity, which represent a

QUINOLINE AND QUINAZOLINE DERIVATIVES HAVING AFFINITY FOR 5HT1-TYPE RECEPTORS

Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.