23879-26-7

Upstream product

• 1527-91-9 N-phenylbenzamidine 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 100-47-0 benzonitrile 
• 62-53-3 aniline 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 108228-39-3 2,3,5-Triphenyl-5,6-dihydro-4(3H)-pyrimidinone 
• 137441-47-5 4-dimethylamino-1,2-diphenyl-5-methyl-5-phenylacetylamino-1,4,5,6-tetrahydropyrimidin-6-one 
• 118824-48-9 N,N-Dimethyl-N'-(4-oxo-1,2,3,3-tetraphenyl-2-azetidinyl)methanimidamide 
• 137441-43-1 5-(4-Chlorobenzoylamino)-4-dimethylamino-1,2-diphenyl-5-methyl-1,4,5,6-tetrahydropyrimidin-6-one 
• 137441-45-3 5-benzoylamino-4-dimethylamino-1,2-diphenyl-5-methyl-1,4,5,6-tetrahydropyrimidin-6-one 
• 142779-59-7 4-dimethylamino-1,2-diphenyl-5-methyl-5-p-methoxybenzoylamino-1,4,5,6-tetrahydropyrimidin-6-one 
• 31730-65-1 2,4-diphenylquinazoline 
• 1527-91-9 N-phenylbenzamidine 
• 56844-90-7 2,4-diphenyl-3,4-dihydro-quinazoline 
• 13707-43-2 N,N-dimethyl-N′-(phenylsulfonyl)formimidamide 
• 130542-35-7 6-Dimethylamino-2,3-diphenyl-3H-pyrimidin-4-one 
• 89069-59-0 2,3-diphenyl-4(3H)-pyrimidinone 
• 79221-03-7 1,4-diphenyl-1H-imidazole 

Relevant academic research and scientific papers

Synthesis of novel 2-phenyl-5-substituted dihydropyrimidines using 2-phenyl-1,3-diaza-1,3-butadienes and electron-deficient olefins

A novel synthetic method for 2,5-disubstituted dihydropyrimidines was developed. The cyclization of 1,3-diaza-4-dimethylamino-1,3-butadienes having a N-protecting group (N-Boc, N-Cbz, N-n-C4H9, N-Bn or N-Ph) with electron-deficient olefins, such as α,β-unsaturated carbonyl compounds, phenyl vinyl sulfone, and acrylonitrile was studied in detail. The cyclization smoothly proceeded to afford 4-dimethylamino-1,4,5,6- tetrahydropyrimidines or 1,6-dihydropyrimidines in good yields. The isolated 4-dimethylamino-1,4,5,6-tetrahydropyrimidines were converted to 2,5-disubstituted-1,6-dihydropyrimidines through the β-elimination of the dimethylamino group. 2,5-Disubstituted-1,4(6)-dihydropyrimidines were obtained after removal of the N-Boc or N-Cbz group. Independent tautomers of the resulting dihydropyrimidines were observed.

NEW SYNTHESIS OF QUINAZOLINE AND BENZOQUINAZOLINE DERIVATIVES

The synthesis of 2-substituted quinazolines II from 1,3-diazabutadienes I and of benzoquinazolines IV and VI from N-naphthylsubstituted amidines III and V the yields being up to 90percent is reported.