23886-52-4Relevant articles and documents
Regioselective biocatalytic hydrolysis of (E,Z)-2-methyl-2-butenenitrile for production of (E)-2-methyl-2-butenoic acid
Hann, Eugenia C.,Sigmund, Amy E.,Fager, Susan K.,Cooling, Frederick B.,Gavagan, John E.,Bramucci, Michael G.,Chauhan, Sarita,Payne, Mark S.,DiCosimo, Robert
, p. 577 - 581 (2007/10/03)
Acidovorax facilis 72W nitrilase catalyzed the regioselective hydrolysis of (E,Z)-2-methyl-2-butenenitrile, producing only (E)-2-methyl-2-butenoic acid with no detectable conversion of (Z)-2-methyl-2-butenenitrile. (E)-2-Methyl-2-butenoic acid, produced in aqueous solution as the ammonium salt, was readily separated from (Z)-2-methyl-2-butenenitrile, and isolated in high yield and purity. The combination of nitrile hydratase and amidase activities of several Comamonas testosteroni strains were also highly regioselective for the production of (E)-2-methyl-2-butenoic acid from (E,Z)-2-methyl-2- butenenitrile.
OXIDATIVE REARRANGEMENT OF ALKANAL CYANOHYDRINS INITIATED BY PEROXYDISULFATE IONS
Ogibin, Yu.N.,Makhova, I.V.,Gorozhankin, S.K.,Nikishin, G.I.
, p. 2099 - 2104 (2007/10/02)
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