23903-48-2

Usage

InChI:InChI=1/C16H14N2OS/c17-10-13-12-8-4-5-9-14(12)20-16(13)18-15(19)11-6-2-1-3-7-11/h1-3,6-7H,4-5,8-9H2,(H,18,19)

Upstream product

• 4651-91-6 3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene 
• 98-88-4 benzoyl chloride 
• 65-85-0 benzoic acid 
• 108-94-1 cyclohexanone 

Downstream Products

• 1262051-88-6 2-phenyl-4,5,6,7-tetrahydrobenzo[b]-4H-thieno[2,3-d][1,3]oxazin-4-imine 

Relevant academic research and scientific papers

4,5,6,7-tetrahydrobenzothiophene compound application

The invention provides an application of a 4,5,6,7-tetrahydrobenzothiophene compound, in particular to an application of a compound with a structure in a formula (I) in preparing a beta-N-acetylhexosaminidase OfHex1 inhibitor. The invention provides that the compound with the structure in the formula (I) has a better inhibiting effect on the beta-N-acetylhexosaminidase OfHex1, can be used for pestcontrol, and has easily available raw materials and less synthesis difficulty, and can be used for industrial development.

Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1)

Identification, synthesis and structure-activity relationship of small-molecule VIPR1 antagonists encompassing two chemical series are described.

Antiarrhythmic, serotonin antagonist and antianxiety activities of novel substituted thiophene derivatives synthesized from 2-amino-4,5,6,7-tetrahydro-N- phenylbenzo[b]thiophene-3-carboxamide

A series of novel thiophene derivatives 3-17 were synthesized by initial reactions of 2-amino-4,5,6,7-tetrahydro-N-phenylbenzo[b]thiophene-3-carboxamide 1 and 2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carbonitrile 7 with different organic reagents. T

N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3

The identification and exploration of a novel, potent and selective series of N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amide inhibitors of JNK2 and JNK3 kinases is described. Compounds 5a and 11a were identified as potent inhibitors of JNK3 (pIC50 6.7 and 6.6, respectively), with essentially equal potency against JNK2 (pIC50 6.5). Selectivity within the mitogen-activated protein kinase (MAPK) family, against JNK1, p38α and ERK2, was observed for the series. X-ray crystallography of 5e and 8a in JNK3 revealed a unique binding mode, with the 3-cyano substituent forming an H-bond acceptor interaction with the hinge region of the ATP-binding site.

Herbicides containing substituted 2-aminothiophenes

A herbicidal composition containing one or more substituted 2-aminothiophenes of the formula I STR1 where R1 and R2 together from a C4 -alkylene chain to which a benzene ring may be fused, R3 is --CN or CX--R6, where R6 is hydroxyl, C1 -C4 -alkoxy or amino, R4 is hydrogen or a phenyl group which may carry one or two nitro radicals, where R8 is hydrogen, C1 -C4 -alkyl or phenyl group R9 is C1 -C20 -alkyl, partially or completely halogenated C1 -C6 -alkyl, C2 -C6 -alkenyl, C6 -cycloalkyl, or amino, C1 -C4 -alkylamino, C3 -C8 -cycloalkylamino, phenyl or phenylamino, where the aromatic moiety may carry at least one of nitro and halogen; R10 is C1 -C4 -alkyl or phenyl, which may carry one C1 -C4 -alkyl radical; R11 is pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl or piperazin-1-yl, where the heterocyclic structures may carry one C1 -C4 -group; R5 is hydrogen; or R4 and R5 together form a group =CR12 R13 or --CO--W--CO--, where R12 is hydrogen, amino, C1 -C4 -alkylamino or C3 -C8 -cycloalkylamino; R13 is amino, C3 -C8 -cycloalkylamino, phenyl or pyridyl, where the two last mentioned substituents may carry at least one halogen or nitro radicals; W is an ethylene or ethenylene bridge, or a 6-membered 1,2-C-bonded aromatic bridge where these bridge members may carry, on each substitutable carbon atom, at least one halogen a 5-membered or 6-membered 1,2-C-bonded cycloalkylene or cycloalkenylene bridge, and the basic salts of the compounds I in which R3 is hydroxycarbonyl or hydroxythiocarbonyl, and the acidic salts of the compounds I which contain a basic nitrogen atom, as antagonistic compounds and one or more herbicidal active ingredients from the group consisting of the cyclohexenone derivatives of the formula III STR2

Derivatives of thiophene

New dicyclic thiophene compounds having the structural formula STR1 wherein X is an ester or cyano group and Y is a substituted amino group. The compounds are useful as agricultural chemicals and particularly as ripeners for sugarcane.

Use of polycyclic thiophene compounds as ripeners for sugarcane

Sucrose yield of sugarcane is increased by treating the cane crop a few weeks prior to harvest with a certain type of polycyclic thiophene compound of the formula SPC1 Wherein X is cyano, carboalkoxy or carbamido and Y is an amino or substituted amino group, or with mixtures comprising one or more such compounds.