23903-53-9

Basic information

• Product Name: 2,5-DIMETHYL-4-OXO-3,4-DIHYDRO-THIENO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2,5-DIMETHYL-4-OXO-3,4-DIHYDRO-THIENO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID ETHYL ESTER;2,5-dimethyl-4-oxo-3H-thieno[5,4-d]pyrimidine-6-carboxylic acid ethyl ester;4-keto-2,5-dimethyl-3H-thieno[5,4-d]pyrimidine-6-carboxylic acid ethyl ester;ethyl 2,5-dimethyl-4-oxo-3H-thieno[5,4-d]pyrimidine-6-carboxylate;ethyl 2,5-dimethyl-4-oxo-3H,4H-thieno[2,3-d]pyrimidine-6-carboxylate
• CAS NO: 23903-53-9
• Molecular Formula: C₁₁H₁₂N₂O₃S
• Molecular Weight: 252.29
• Mol File: 23903-53-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 340.3°C at 760 mmHg
• Flash Point: 159.6°C
• Appearance: /
• Density: 1.44g/cm³
• Vapor Pressure: 4.4E-05mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: 2,5-DIMETHYL-4-OXO-3,4-DIHYDRO-THIENO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHYL-4-OXO-3,4-DIHYDRO-THIENO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID ETHYL ESTER(23903-53-9)
• EPA Substance Registry System: 2,5-DIMETHYL-4-OXO-3,4-DIHYDRO-THIENO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID ETHYL ESTER(23903-53-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 23903-53-9(Hazardous Substances Data)

Usage

General Description

2,5-DIMETHYL-4-OXO-3,4-DIHYDRO-THIENO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID ETHYL ESTER is a chemical compound with a complex structure that includes a thiophene ring and a pyrimidine ring. It also contains a carboxylic acid and an ethyl ester functional group. 2,5-DIMETHYL-4-OXO-3,4-DIHYDRO-THIENO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID ETHYL ESTER has potential applications in pharmaceuticals, agrochemicals, and materials science due to its unique structure and properties. It may be used as a building block in the synthesis of various bioactive molecules and as a potential lead compound for drug discovery. Its properties and potential uses make it an interesting target for further research and development in the chemical and pharmaceutical industries.

InChI:InChI=1/C11H12N2O3S/c1-4-16-11(15)8-5(2)7-9(14)12-6(3)13-10(7)17-8/h4H2,1-3H3,(H,12,13,14)

Upstream product

• 23903-49-3 5-acetylamino-4-cyano-3-methyl-thiophene-2-carboxylic acid ethyl ester 
• 4815-30-9 diethyl 5-amino-3-methyl-2,4-thiophenedicarboxylate 
• 75-05-8 acetonitrile 
• 1083065-68-2 5-ethyl 2-acetamido-3-(phenylmethylenehydrazide)-4-methylthiophenecarboxylate 
• 1083065-69-3 5-ethyl 2-acetamido-3-(4-chlorophenylmethylenehydrazide)-4-methylthiophenecarboxylate 
• 1083065-70-6 5-ethyl 2-acetamido-3-(4-methoxyphenylmethylenehydrazide)-4-methylthiophenecarboxylate 
• 23903-46-0 ethyl 2-amino-3-cyano-4-methylthiophene-5-carboxylate 
• 62-55-5 thioacetamide 

Downstream Products

• 917087-82-2 Ethyl 3-benzyl-2,5-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]-pyrimidine-6-carboxylate 
• 148838-70-4 ethyl 4-chloro-2,5-dimethylthieno[2,3-d]pyrimidine-6-carboxylate 

Relevant articles and documents

A novel microwave-assisted green synthesis of condensed 2-substituted-pyrimidin-4(3H)-ones under solvent-free conditions

A rapid microwave-assisted green chemical synthesis of condensed 2-substituted-pyrimidin-4(3H)-ones 3, 4, and 5 involving the condensation of a variety of nitriles with o-aminoesters of thiophene 2a-e, benzene 2f, dimethoxybenzene 2g and quinazolinone 2h in the presence of catalytic amount of HCl alone or with the Lewis acid AlCl3 under solvent-free conditions, is described for the first time. This novel and clean one-pot methodology, which is characterized by very short reaction times and easy workup procedures, can be exploited to generate a diverse library of condensed pyrimidine heterocycles.

New thieno compounds. Part 14: Synthesis of 4 amino-substituted thieno[2,3-d]pyrimidine-6-carboxylic acid derivatives

The combination of a basic and a carboxylic ester group in the thieno[2,3-d]pyrimidine structure could give interesting biological activities. Starting from the diester of 2-amino-4-methylthiophene-3,5-diacid the ethylesters of 3,4-dihydro-5-methyl-4-oxot