23903-53-9Relevant academic research and scientific papers
A novel microwave-assisted green synthesis of condensed 2-substituted-pyrimidin-4(3H)-ones under solvent-free conditions
Jain, Kishor S.,Bariwal, Jitender B.,Phoujdar, Manisha S.,Nagras, Madhuri A.,Amrutkar, Rakesh D.,Munde, Manoj K.,Tamboli, Riyaj S.,Khedkar, Samrat A.,Khiste, Rahul H.,Vidyasagar, Nikhil C.,Dabholkar, Vinit V.,Kathiravan
body text, p. 178 - 185 (2009/07/19)
A rapid microwave-assisted green chemical synthesis of condensed 2-substituted-pyrimidin-4(3H)-ones 3, 4, and 5 involving the condensation of a variety of nitriles with o-aminoesters of thiophene 2a-e, benzene 2f, dimethoxybenzene 2g and quinazolinone 2h in the presence of catalytic amount of HCl alone or with the Lewis acid AlCl3 under solvent-free conditions, is described for the first time. This novel and clean one-pot methodology, which is characterized by very short reaction times and easy workup procedures, can be exploited to generate a diverse library of condensed pyrimidine heterocycles.
Design and synthesis of 3-pyrazolyl-thiophene, thieno[2,3-d]pyrimidines as new bioactive and pharmacological activities
Hafez,El-Gazzar
experimental part, p. 5222 - 5227 (2009/05/07)
Two series of 5-ethyl-2-amino-3-pyrazolyl-4-methylthiophenecarboxylate and 2-thioxo-N3-aminothieno[2,3-d]pyrimidines were prepared from 3,5-diethyl-2-amino-4-methylthio-phenecaboxylate and evaluated as anti-inflammatory, analgesic and ulcerogen
New thieno compounds. Part 14: Synthesis of 4 amino-substituted thieno[2,3-d]pyrimidine-6-carboxylic acid derivatives
Baumgartner,Pech,Bohm
, p. 192 - 194 (2007/10/02)
The combination of a basic and a carboxylic ester group in the thieno[2,3-d]pyrimidine structure could give interesting biological activities. Starting from the diester of 2-amino-4-methylthiophene-3,5-diacid the ethylesters of 3,4-dihydro-5-methyl-4-oxot
Reaction of Nitriles under Acidic Conditions. Part I. A General Method of Synthesis of Condensed Pyrimidines
Dave, K. G.,Shishoo, G. J.,Devani, M. B.,Kalyanaraman, R.,Ananthan, S.,et. al.
, p. 1497 - 1500 (2007/10/02)
Nitriles are known to give rise to salts of different compositions with halogen acids.Many of the reactions undergone by nitriles under the influence of halogen acids are, in many cases, assumed to proceed via the intermediate formation of highly reactive
