239088-19-8

Basic information

• Product Name: Decyl(2-hydroxyethyl)-carbaMic Acid 9H-Fluoren-9-ylMethyl Ester
• Synonyms: Decyl(2-hydroxyethyl)-carbaMic Acid 9H-Fluoren-9-ylMethyl Ester
• CAS NO: 239088-19-8
• Molecular Formula: C₂₇H₃₇NO₃
• Molecular Weight: 424
• Product Categories: Amines;Aromatics;Amines, Aromatics
• Mol File: 239088-19-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 568.2±29.0 °C(Predicted)
• Appearance: /
• Density: 1.079±0.06 g/cm3(Predicted)
• PKA: 14.59±0.10(Predicted)
• CAS DataBase Reference: Decyl(2-hydroxyethyl)-carbaMic Acid 9H-Fluoren-9-ylMethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Decyl(2-hydroxyethyl)-carbaMic Acid 9H-Fluoren-9-ylMethyl Ester(239088-19-8)
• EPA Substance Registry System: Decyl(2-hydroxyethyl)-carbaMic Acid 9H-Fluoren-9-ylMethyl Ester(239088-19-8)

Safety Data

• Hazardous Substances Data: 239088-19-8(Hazardous Substances Data)

Usage

Uses

Decyl(2-hydroxyethyl)-carbamic Acid 9H-Fluoren-9-ylmethyl Ester is used in the preparation of vancomycin-related antibacterial agents.

Upstream product

• 41233-29-8 methanesulfonic acid decyl ester 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 15196-28-8 2-(n-Decylamino)ethanol 
• 112-30-1 1-Decanol 

Downstream Products

• 239088-22-3 N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester 

Relevant articles and documents

Synthesis method of special-pulling universal intermediate (by machine translation)

To the invention, 9 - 2, 2, 6 tetramethylpiperidine oxide (TEMPO) is used as an oxidizing agent, the reaction temperature 6 - is lower, Fmoc-Cl is protected and oxidized to obtain N - (0 °C fluorenylmethoxycarbonyl) decyl aminoacetaldehyde. TEMPO oxidation is simple, the reaction temperature is mild, pH value and reaction temperature of the reaction liquid are controlled. (by machine translation)

Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci

Lipophilic substitution on vancomycin is an effective strategy for the development of novel vancomycin analogues against drug-resistant bacteria by enhancing bacterial cell wall interactions. However, hydrophobic structures usually lead to long elimination half-life and accumulative toxicity; therefore, hydrophilic fragments were also introduced to the lipo-vancomycin to regulate their pharmacokinetic/pharmacodynamic properties. Here, we synthesized a series of new vancomycin analogues carrying various sugar moieties on the seventh-amino acid phenyl ring and lipophilic substitutions on vancosamine with extensive structure-activity relationship analysis. The optimal analogues indicated 128-1024-fold higher activity against methicillin-susceptible S. aureus, vancomycin-intermediate resistant S. aureus (VISA), and vancomycin-resistant Enterococci (VRE) compared with that of vancomycin. In vivo pharmacokinetics studies demonstrated the effective regulation of extra sugar motifs, which shortened the half-life and addressed concerns of accumulative toxicity of lipo-vancomycin. This work presents an effective strategy for lipo-vancomycin derivative design by introducing extra sugars, which leads to better antibiotic-like properties of enhanced efficacy, optimal pharmacokinetics, and lower toxicity.

Process for preparing glycopeptide phosphonate derivatives

Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.