23912-61-0Relevant academic research and scientific papers
Identification of 1,5,7-Triazabicyclododecene and Polystyrene-Supported Superbases as Efficient Hydroxylaminolysis Agents of Sterically Hindered and Epimerizable Esters
Pierre, Romain,Gaigne, Frédéric,El-Bazbouz, Ghizlane,Mouis, Grégoire,Ouvry, Gilles,Tomas, Loic,Harris, Craig S.
, p. 1102 - 1106 (2018)
In modern pharmaceutical research, the need for reliable protocols for the preparation of chemical libraries in a controlled manner is quintessential to driving the Design-Make-Test cycle in drug discovery programs. In this letter, we communicate the iden
In silico design of HDAC6 inhibitors with neuroprotective effects
Bello, Martiniano,de Pedro, Nuria,Correa-Basurto, José,Gómez-Vidal, José Antonio,Rosales-Hernández, Martha Cecilia,Sixto-López, Yudibeth
, (2021/11/24)
HDAC6 has emerged as a molecular target to treat neurodegenerative disorders, due to its participation in protein aggregate degradation, oxidative stress process, mitochondrial transport, and axonal transport. Thus, in this work we have designed a set of
A convenient procedure for the solid-phase synthesis of hydroxamic acids on PEGA resins
Nandurkar, Nitin S.,Petersen, Rico,Qvortrup, Katrine,Komnatnyy, Vitaly V.,Taveras, Kennedy M.,Le Quement, Sebastian T.,Frauenlob, Robin,Givskov, Michael,Nielsen, Thomas E.
supporting information; experimental part, p. 7121 - 7124 (2012/01/14)
An efficient method for the solid-phase synthesis of hydroxamic acids is described. The method comprises the nucleophilic displacement of esters immobilized on PEGA resins with hydroxylamine/sodium hydroxide in isopropanol. The hydroxyaminolysis protocol
