239136-81-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-2,2-difluoro-N-(2-hydroxyphenyl)acetamide is used as a key intermediate for the synthesis of various drugs and biologically active compounds. Its role in the production process is essential due to its ability to contribute to the formation of complex molecular structures that possess therapeutic properties.
Used in Medicinal Chemistry and Drug Discovery:
In the field of medicinal chemistry, 2-Bromo-2,2-difluoro-N-(2-hydroxyphenyl)acetamide is utilized as a building block for the research and development of new medications. Its unique structural features make it a promising candidate for the design of innovative pharmaceutical agents that can address unmet medical needs.
Used in Research and Development:
2-Bromo-2,2-difluoro-N-(2-hydroxyphenyl)acetamide is also employed in the research and development phase of pharmaceuticals. It aids scientists and researchers in understanding the compound's potential interactions with biological targets, which is vital for optimizing drug efficacy and safety.

InChI:InChI=1/C8H6BrF2NO2/c9-8(10,11)7(14)12-5-3-1-2-4-6(5)13/h1-4,13H,(H,12,14)

Upstream product

• 186828-50-2 2-(1-bromodifluoromethyl)benzo-1,3-oxazole 
• 667-27-6 Ethyl bromodifluoroacetate 
• 95-55-6 2-amino-phenol 

Relevant academic research and scientific papers

Synthesis of 2-Fluoro-1,4-benzoxazines and 2-Fluoro-1,4-benzoxazepin-5-ones by Exploring the Nucleophilic Vinylic Substitution (SNV) Reaction of gem-Difluoroenamides

N-Benzoyl β,β-difluoroenamides and N-benzoyl fluoroynamides are novel structural units which have been explored as precursors in heterocyclic synthesis. The presence of two fluorine atoms at the β-position of the enamide moiety endows unique electrophilic

Photocatalytic reductive radical-radical coupling of: N, N ′-cyclicazomethine imines with difluorobromo derivatives

A visible-light-induced difluoroalkylation of N,N′-cyclicazomethine imine was successfully realized through a novel photoredox radical-radical cross-coupling reaction. This developed protocol exhibits high functional group tolerance and affords a variety

Copper-Catalyzed Fluoroolefination of Silyl Enol Ethers and Ketones toward the Synthesis of β-Fluoroenones

A general and facile synthetic method for β-fluoroenones from silyl enol ethers or ketones, with a copper-amine catalyst system, has been developed. The reaction proceeded by a tandem process of difluoroalkylation-hydrolysis-dehydrofluorination. This method is characterized by high yields, excellent Z/E ratios, a low-cost catalyst, and a broad substrate scope. The synthetic potential of β-fluoroenones has been demonstrated by the construction of various complicated organofluorine molecules.

Synthesis and reactivity of halogeno-difluoromethyl aromatics and heterocycles: Application to the synthesis of gem-difluorinated bioactive compounds

In an effort to prepare new fluorine-containing compounds which are active against HIV, and based on the electrochemical reduction of a series of bromodifluoromethyl compounds, the tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective reduct

Syntheses of 2-(bromodifluoromethyl)benzoxazole and 5-(bromodifluoromethyl)-1,2,4-oxadiazoles

Facile syntheses of CF2Br-substituted heterocycles are reported. Preparation of 2-(bromodifluoromethyl)benzoxazole (2) was achieved in two steps by reaction of 2-aminophenol (3) with CF2BrCO2Et to give amide (4), followed by cyclization of 4 with PPA to give 2. The 5-(bromodifluoromethyl)-1,2,4-oxadiazoles (6a-c) were prepared by one step reaction of amidoximes (5a-c) with CF2BrCO2Et. These CF2Br-substituted heterocycles are intermediates in an ongoing investigation of the synthesis of inhibitors of HIV reverse transcriptase having a CF2 substitution.