23916-77-0Relevant academic research and scientific papers
Arylpiperazinylalkyl-3(2-H)-pyridazinones
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, (2008/06/13)
A description is given of new arylpiperazinylalkyl-3(2H)-pyridazinones of general formula (I) and their preparation and their addition salts with pharmaceutically acceptable acids, in which R1is a methyl or phenyl radical, R2is a hyd
Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
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, (2008/06/13)
Substituted 6-phenyl-3(2H)-pyridazinone compounds are useful as cardiotonic agents. Said compounds cause a significant increase in myocardial contractility in the anesthetized dog. Said compounds are produced by reacting substituted γ-oxobenzenebutanoic acids with suitably substituted hydrazines to provide 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are dehydrogenated to the desired product. The intermediate 6-phenyl-4,5-dihydro-3(2H)-pyridazinones are themselves useful as cardiotonic agents.
Pyridazinones. 3. Synthesis, Antisecretory, and Antiulcer Activities of 2-Cyanoguanidine Derivatives
Yamada, Toshihiro,Shimamura, Hiroshi,Tsukamoto, Yoshitsugu,Yamaguchi, Azuma,Ohki, Masahiko
, p. 1144 - 1149 (2007/10/02)
3(2H)-Pyridazinone derivatives having a 2-cyanoguanidine moiety, as well as a sulfur or an oxygen atom in the alkylene side chain, were synthesized and evaluated for gastric antisecretory and antiulcer activities.The key intermediates, free amines having
VINYLATION OF 3-PYRIDAZONES
Shatalov, G.V.,Gridchin, S.A.,Mikhant'ev, B.I.
, p. 299 - 302 (2007/10/02)
The vinylation of 3-pyridazones through a step involving the production of 2-hydroxy- and 2-chloroethyl-substituted compounds with subsequent dehydrochlorination, as well as vinylation by means of vinyl acetate, in all cases leads only to N-vinyl derivati
