23933-83-7

Usage

Uses

Used in Organic Synthesis:
2-AMINO-1-(4'-CHLORO-PHENYL)-PROPAN-1-OL is utilized as a key intermediate in organic synthesis for the construction of a variety of complex organic molecules. Its presence in these reactions is crucial due to its ability to form multiple types of chemical bonds, facilitating the synthesis of diverse chemical entities.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-AMINO-1-(4'-CHLORO-PHENYL)-PROPAN-1-OL is employed as a building block for the development of new drugs. Its unique structure allows for the creation of molecules with potential therapeutic properties, making it a valuable asset in drug discovery and design processes.
Used in Agrochemical Development:
2-AMINO-1-(4'-CHLORO-PHENYL)-PROPAN-1-OL also finds application in the agrochemical sector, where it is used as an intermediate in the synthesis of compounds with pesticidal or herbicidal properties. Its contribution to the development of effective and environmentally friendly agrochemicals is significant.
Used in Drug Development:
Due to its potential biological activity, 2-AMINO-1-(4'-CHLORO-PHENYL)-PROPAN-1-OL is considered in the development of new drugs. Its structural features may contribute to the creation of bioactive compounds with therapeutic applications in various medical fields.

Upstream product

• 52483-67-7 N-[(1RS,2SR)-2-(4-chloro-phenyl)-2-hydroxy-1-methyl-ethyl]-acetamide 
• 27852-91-1 1-(4-chlorophenyl)-2-nitro-propan-1-ol 

Downstream Products

• 92551-52-5 N-[5c-(4-chloro-phenyl)-4r-methyl-oxazolidin-3-ylmethyl]-maleimide 
• 94256-02-7 N-[5c-(4-chloro-phenyl)-4r-methyl-oxazolidin-3-ylmethyl]-phthalimide 
• 92645-34-6 N-[5c-(4-chloro-phenyl)-4r-methyl-oxazolidin-3-ylmethyl]-succinimide 
• 1084926-95-3 C₁₄H₂₀ClNO₃ 

Relevant academic research and scientific papers

Synthesis method and application of 2-amino-1-(4-chlorphenyl) propane-1-ol

The invention relates to a method for synthesizing a hexythiazox key intermediate and application of the hexythiazox key intermediate. The synthesis method comprises the following steps: 1) carrying out oxidation reaction on 1-(4-chlorphenyl) propyl-1-ene-2-yloxytrimethylsilane and m-chloroperoxybenzoic acid to generate an intermediate I; 2) adding K2CO3 into the intermediate I, and hydrolyzing to obtain 1-(4-chlorphenyl)-1-hydroxypropane-2-one; 3) adding TiCI4/NH4CL into 1-(4-chlorphenyl)-1-hydroxypropane-2-one, and carrying out a reaction to obtain an intermediate II; and 4) adding sodium cyanoborohydride into the intermediate II, and carrying out reduction to obtain 2-amino-1-(4-chlorphenyl) propane-1-ol. According to the invention, the prepared2-amino-1-(4-chlorphenyl) propane-1-ol is as high as 95.8% in yield, low in cost, as high as 98.5% in purity and good in quality; and the 2-amino-1-(4-chlorphenyl) propane-1-ol prepared by the method disclosed by the invention is used for preparing hexythiazox.

An efficient reduction protocol for the synthesis of β-hydroxycarbamates from β-nitro alcohols in one pot: a facile synthesis of (-)-β-conhydrine

An efficient and practical one-pot protocol for the reduction of β-nitro alcohols to their corresponding N-(tert-butoxycarbonyl) amino alcohols using Zn-NH4Cl in aqueous methanol is described. Other reducible groups such as ketones and isolated double bonds remained intact. This methodology allows a short synthesis of (-)-β-conhydrine to be achieved.

Process for producing optically active 3,3,3-Trifluoro-2-Hydroxy-2-Methylpropionic acid, and salt thereof

There are disclosed are a diastereomer salt of formula (1): a process for producing the same, a process for producing optically active 3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid of formula (2′): a novel optically active amine compound of formula (4): a novel optically active amine compound of formula (8): an imine compound of formula (7) or (11):