23943-56-8

Basic information

• Product Name: P,P-diphenyl-N-[(1R)-1-phenylethyl]phosphinic amide
• Synonyms: P,P-diphenyl-N-[(1R)-1-phenylethyl]phosphinic amide
• CAS NO: 23943-56-8
• Molecular Weight: 321.359
• Mol File: 23943-56-8.mol
• Article Data: 41

Chemical Properties

• CAS DataBase Reference: P,P-diphenyl-N-[(1R)-1-phenylethyl]phosphinic amide(CAS DataBase Reference)
• NIST Chemistry Reference: P,P-diphenyl-N-[(1R)-1-phenylethyl]phosphinic amide(23943-56-8)
• EPA Substance Registry System: P,P-diphenyl-N-[(1R)-1-phenylethyl]phosphinic amide(23943-56-8)

Safety Data

• Hazardous Substances Data: 23943-56-8(Hazardous Substances Data)

Upstream product

• 544-97-8 dimethyl zinc(II) 
• 98837-46-8 N-benzylidenediphenylphosphinamide 
• 82572-06-3 P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 1499-21-4 Diphenylphosphinic chloride 
• 82944-84-1 N-[(1E)-1-phenylethylidene]-P,P-diphenylphosphinic amide 
• 613-91-2 acetophenone oxime 
• 1079-66-9 chloro-diphenylphosphine 
• 98837-46-8 P,P-diphenyl-N-(phenylmethylene)phosphinic amide 
• 75-24-1 trimethylaluminum 
• 5994-87-6 diphenylphosphinamide 
• 98-86-2 acetophenone 

Downstream Products

• 2354-91-8 N-<(R)-(+)-α-phenylethyl>-2,2,2-trifluoroacetamide 

Relevant articles and documents

Copper(I)-catalyzed asymmetric hydrosilylations of imines at ambient temperatures

Are you looking for an operationally simple means of preparing enantio-enriched benzylic-like centers bearing nitrogen? Consider this new and convenient alternative to asymmetric hydrogenation: CuH when ligated by an enantio-pure SEGPHOS ligand can cataly

Asymmetric reduction method of nitrogen-phosphonyl protected imine

The invention discloses an asymmetric reduction method of nitrogen phosphonyl protective imine. The nitrogen phosphonyl protective imine is reduced into chiral amine in a hydrogen atmosphere under theaction of a metal catalyst and alkali, and the metal catalyst is prepared from a metal iridium complex and a nitrogen-phosphorus chiral ligand. The method provided by the invention has the characteristics of high enantioselectivity, high yield and high conversion number (TON). The method can be used for synthesizing various substituted chiral amines, can be used as an important intermediate for preparing various medicines, and has important significance for industrial production of medicines.

Asymmetric Transfer Hydrogenation in Thermomorphic Microemulsions Based on Ionic Liquids

A thermomorphic ionic-liquid-based microemulsion system was successfully applied for the Ru-catalyzed asymmetric transfer hydrogenation of ketones. On the basis of the temperature-dependent multiphase behavior of the targeted microemulsion, simple product separation as well as catalyst recycling could be realized. The use of water-soluble ligands improved the immobilization of the catalyst in the microemulsion phase and significantly decreased the catalyst leaching into the organic layer upon extraction of the product. Eventually, the optimized microemulsion system could be applied to a wide range of aromatic ketones that were reduced with good isolated yields (up to 98%) and enantioselectivities (up to 97%), while aliphatic ketones were less successful.

Iron(II)/(NH)2P2 Macrocycles: Modular, Highly Enantioselective Transfer Hydrogenation Catalysts

A generalized protocol for the synthesis of chiral (NH)2P2 macrocycles allows changing the linker between the phosphines and gives access to a family of such ligands, as demonstrated for the propane-1,3-diyl analogue. The corresponding complexes based on earth-abundant and nontoxic iron were applied as catalysts in the asymmetric transfer hydrogenation of polar double bonds. Thanks to the ligand modularity and to the use of tunable isonitriles as ancillary ligands, the catalyst system can be individually optimized for each substrate to give high enantioselectivity (up to 99.9% conversion and 99.6% ee, TOF up to >3950 h-1) for a broad scope of 26 substrates.