23943-96-6

Basic information

• Product Name: (R)-(+)-2-METHOXYPROPIONIC ACID
• Synonyms: (R)-(-)-2-METHOXYPROPIONIC ACID;(R)-(+)-2-METHOXYPROPIONIC ACID;RARECHEM AL BO 1221;(2R)-2-Methoxypropionic acid;(R)-(+)-2-Methoxypropionic acid,97%;(R)-2-Methoxypropanoic Acid
• CAS NO: 23943-96-6
• Molecular Formula: C₄H₈O₃
• Molecular Weight: 104.1
• Product Categories: Chiral Reagents
• Mol File: 23943-96-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 108-110°C/30 mm
• Flash Point: 87.1°C
• Appearance: Clear colorless/Liquid
• Density: 1.1141 (rough estimate)
• Vapor Pressure: 0.144mmHg at 25°C
• Refractive Index: 1.4132-1.4152
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 3.59±0.10(Predicted)
• CAS DataBase Reference: (R)-(+)-2-METHOXYPROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-2-METHOXYPROPIONIC ACID(23943-96-6)
• EPA Substance Registry System: (R)-(+)-2-METHOXYPROPIONIC ACID(23943-96-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 37/39-26-39
• Hazardous Substances Data: 23943-96-6(Hazardous Substances Data)

Usage

Chemical Properties

Liquid

Uses

(R)-(+)-2-Methoxypropionic Acid (cas# 23943-96-6) is a compound useful in organic synthesis.

InChI:InChI=1/C4H8O3/c1-3(7-2)4(5)6/h3H,1-2H3,(H,5,6)/p-1/t3-/m1/s1

Upstream product

• 547-64-8 methyl lactate 
• 74-88-4 methyl iodide 
• 1257267-05-2 C₁₂H₁₅NO₅ 
• 17639-76-8 methyl 2-methoxypropionate 
• 139265-30-8 (R)-2-Methoxy-propionic acid 4-nitro-phenyl ester 
• 124-41-4 sodium methylate 
• 598-72-1 2-Bromopropionic acid 
• 54656-63-2 methyl (2R)-2-methoxypropanoate 

Downstream Products

• 1220626-86-7 (R)-N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-methoxypropanamide 
• 1345848-18-1 (R)-N-(2,5-difluoro-4-((2-(2-methoxypropanamido)pyridin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1231924-04-1 (R)-2-methoxy-1-(4-(3-(4-(5-methylpyridin-2-ylamino)phenoxy)pyrazin-2-yl)piperidin-1-yl)propan-1-one 
• 139265-30-8 (R)-2-Methoxy-propionic acid 4-nitro-phenyl ester 

Relevant articles and documents

Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii

The outer surfaces of mycobacteria, including the organism that causes tuberculosis, are decorated with an array of immunomodulatory glycans. Among these are lipooligosaccharides (LOSs), a class of molecules for which the function remains poorly understoo

Enantioselective syntheses of α-amino-β-hydroxy acids, [15N]-L-allothreonine and [15N]-L-threonine

The enantioselective synthesis of [15N]-L-allothreonine from ethyl (S)-lactate via methyl (S)-3-methoxymethoxy-2-oxobutanoate 15 is described. The stereogenic centre at C-2 was established by a one-pot, dual enzyme catalysed hydrolysis of the ester (by a lipase) and reductive amination of the ketone of 15 (with leucine dehydrogenase) to give, after deprotection, [15N]-(2S,3S)-2-amino-3-hydroxybutanoic acid as a single diastereomer in 93% yield. [15N]-L-Threonine was prepared by an analogous strategy from methyl (R)-lactate using phenylalanine dehydrogenase in the reductive amination step. This approach may be simply adapted for the incorporation of deuterium and carbon-13.

Comparison of deacylation rates of chymotryptic catalysis within an enantiomeric pair of p-nitrophenyl esters

p-Nitrophenyl esters carrying a chiral acyl group were synthesized. These compounds were shown to meet the requirements of chymotrypsin for both the specific binding and the acylation. Therefore, the behavior of p-nitrophenyl esters with chymotrypsin is c