17639-76-8

Basic information

• Product Name: METHYL 2-METHOXYPROPIONATE
• Synonyms: (R,S)-2-Methoxy-propionicacidmethylester;2-methoxy-propanoicacimethylester;Methyl2-methoxypropanoate;Propanoicacid,2-methoxy-,methylester;R,S-2-Methoxy-propionicacidmethylester;METHYL 2-METHOXYPROPIONATE;2-Methoxypropanoic acid methyl ester
• CAS NO: 17639-76-8
• Molecular Formula: C₅H₁₀O₃
• Molecular Weight: 118.13
• EINECS: 241-622-4
• Mol File: 17639-76-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 43-44°C
• Flash Point: 36°C
• Appearance: /
• Density: 0.973g/cm³
• Vapor Pressure: 7.45mmHg at 25°C
• Refractive Index: 1.3970
• Water Solubility: Soluble in water.
• BRN: 1720819
• CAS DataBase Reference: METHYL 2-METHOXYPROPIONATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-METHOXYPROPIONATE(17639-76-8)
• EPA Substance Registry System: METHYL 2-METHOXYPROPIONATE(17639-76-8)

Safety Data

• Statements: 11-36/37/38
• Safety Statements: 16-26-36
• RIDADR: 3272
• TSCA: Yes
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 17639-76-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 17639-76-8 differently. You can refer to the following data:
1. Methyl 2-Methoxypropionate is used as a reagent in the synthesis of 2-methoxy-2-methyl-3-{6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}propanoic acid which is a dual PPARα/γ agonist.
2. Methyl 2-methoxypropionate, is used as a pharmaceutical intermediate.

InChI:InChI=1/C5H10O3/c1-4(7-2)5(6)8-3/h4H,1-3H3

Upstream product

• 5445-17-0 Methyl 2-bromopropionate 
• 124-41-4 sodium methylate 
• 470-23-5 D-fructose 
• 9004-34-6 cellulose 
• 2280-44-6 D-Glucose 
• 97-64-3 ethyl 2-hydroxypropionate 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 547-64-8 methyl lactate 
• 27871-49-4 (S)-Methyl lactate 
• 849585-22-4 LACTIC ACID 
• 73246-45-4 methyl-(S)-2-chloropropionate 
• 109-89-7 diethylamine 
• 3043-33-2 2-methyl-2,3-pentadiene 

Downstream Products

• 22543-21-1 2-methoxy-propionic acid amide 
• 4324-37-2 2-methoxypropionic acid 
• 23943-96-6 (R)-(+)-2-methoxypropionic acid 
• 130050-99-6 methyl 4-O-benzyl-3-O-(benzyloxymethyl)-5-deoxy-2-C-methyl-2-O-methyl-L-arabinonate 
• 130051-00-2 methyl 4-O-benzyl-3-O-(benzyloxymethyl)-5-deoxy-2-C-methyl-2-O-methyl-4-O-L-lyxonate 
• 130050-98-5 methyl 4-O-benzyl-3-O-(benzyloxymethyl)-5-deoxy-2-C-methyl-2-O-methyl-L-ribonate 
• 130050-98-5 (S)-4-Benzyloxy-3-benzyloxymethoxy-2-methoxy-2-methyl-pentanoic acid methyl ester 
• 433301-01-0 (E)-10-(2,2-Diphenyl-cyclopropyl)-3-hydroxy-2-methoxy-2-methyl-dec-9-enoic acid methyl ester 
• 433301-00-9 (E)-9-(2,2-Diphenyl-cyclopropyl)-3-hydroxy-2-methoxy-2-methyl-non-8-enoic acid methyl ester 
• 53772-78-4 perfluorodimethoxymethane 
• 130192-75-5 (3R,4S,5S)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-3,5-dimethyl-dihydro-furan-2-one 
• 130050-89-4 Methyl (2S,3S,4S)-3-hydroxy-2-methyl-2-methoxy-4-<(1,1-dimethylethyldiphenylsilyl)oxy>pentanoate 
• 130050-90-7 (2R,3S,4S)-4-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-2-methoxy-2-methyl-pentanoic acid methyl ester 
• 97562-15-7 methyl 4-O-benzyl-5-deoxy-2-C-methyl-2-O-methyl-L-xylonate 

Relevant articles and documents

Direct conversion of cellulose to high-yield methyl lactate over Ga-doped Zn/H-nanozeolite Y catalysts in supercritical methanol

For realizing sustainable bio-based refineries, it is crucial to obtain high yields of value-added chemicals via the direct conversion of cellulose and lignocellulosic biomass. Although the conversion of cellulose using homogeneous catalysts has been demonstrated to be quite successful, low cellulose conversion and poor product selectivity have been observed using heterogeneous catalysts. In this study, for the first time, the efficient conversion of cellulose to lactic acid derivatives, which can be used as a green solvent and a potential precursor for fine chemicals and biodegradable polymers, over a Ga-doped Zn/H-nanozeolite Y (Ga-doped Zn/HNZY) catalyst is described. Under optimized conditions at 280°C in supercritical methanol, methyl lactate (ML) and methyl 2-methoxypropionate (MMP) are obtained in yields of 57.8% and 12.8%, respectively, from cellulose; these values are greater than those reported in previous studies conducted using heterogeneous catalysts. Using oakwood, ML and MMP are obtained in yields of 12.3% and 18.6%, respectively. A large external surface area of the HNZY support and the synergistic effect of Ga doping on ZnO enhance Lewis acid sites with the simultaneous decrease of the Br?nsted acid sites. This unique catalyst (Ga-doped Zn/HNZY) is beneficial for controlling the consecutive reaction pathways of the decomposition of cellulose to glucose, retro-aldol condensation to trioses, and intramolecular Cannizzaro reaction to ML.

PRODUCTION OF ALKYL ESTERS OF ACRYLIC ACID

A process for producing a mixture including acrylic acid or derivatives thereof, the process including the step of contacting a mixture of lactic acid or derivatives thereof and a solvent over a dehydration catalyst to produce the mixture including alkyl esters of acrylic acid, wherein the density of the solvent ranges from about 10 to about 500 kg/m3 under operating conditions.

Catalytic Gas-Phase Production of Lactide from Renewable Alkyl Lactates

A new route to lactide, which is a key building block of the bioplastic polylactic acid, is proposed involving a continuous catalytic gas-phase transesterification of renewable alkyl lactates in a scalable fixed-bed setup. Supported TiO2/SiO2 catalysts are highly selective to lactide, with only minimal lactide racemization. The solvent-free process allows for easy product separation and recycling of unconverted alkyl lactates and recyclable lactyl intermediates. The catalytic activity of TiO2/SiO2 catalysts was strongly correlated to their optical properties by DR UV/Vis spectroscopy. Catalysts with high band-gap energy of the supported TiO2 phase, indicative of a high surface spreading of isolated Ti centers, show the highest turnover frequency per Ti site.