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N,N-dimethyl-3-(pentafluoroethyl)aniline is an organic compound with the chemical formula C9H10F5N. It is a derivative of aniline, where two methyl groups are attached to the nitrogen atom, and a pentafluoroethyl group is attached to the 3-position of the benzene ring. N,N-dimethyl-3-(pentafluoroethyl)aniline is characterized by its unique combination of electron-donating and electron-withdrawing groups, which can influence its reactivity and physical properties. It is often used in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals due to its potential to modulate the properties of the final products. The presence of fluorine atoms in the molecule can significantly alter the lipophilicity, metabolic stability, and other pharmacokinetic properties of the compounds in which it is incorporated.

2396-08-9

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2396-08-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2396-08-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,9 and 6 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2396-08:
(6*2)+(5*3)+(4*9)+(3*6)+(2*0)+(1*8)=89
89 % 10 = 9
So 2396-08-9 is a valid CAS Registry Number.

2396-08-9Downstream Products

2396-08-9Relevant academic research and scientific papers

Stoichiometric and Catalytic Aryl-Perfluoroalkyl Coupling at Tri-tert-butylphosphine Palladium(II) Complexes

Ferguson, Devin M.,Bour, James R.,Canty, Allan J.,Kampf, Jeff W.,Sanford, Melanie S.

, p. 11662 - 11665 (2017)

This Communication describes studies of Ph-RF (RF = CF3 or CF2CF3) coupling at Pd complexes of general structure (PtBu3)PdII(Ph)(RF). The CF3 analogue participates in fast Ph-CF3 coupling (II complex. Furthermore, they show that this undesired pathway can be circumvented by changing from a CF3 to a CF2CF3 ligand. Ultimately, the insights gained from stoichiometric studies enabled the identification of Pd(PtBu3)2 as a catalyst for the Pd-catalyzed cross-coupling of aryl bromides with TMSCF2CF3 to afford pentafluoroethylated arenes.

The first nucleophilic C-H perfluoroalkylation of aromatic compounds via (arene)tricarbonylchromium complexes

Kirij, Natalia V.,Filatov, Andrey A.,Khrapach, Gleb Yu.,Yagupolskii, Yurii L.

supporting information, p. 2146 - 2149 (2017/02/19)

The first nucleophilic perfluoroalkylation of arenes is based on the arene π-system activation via (η6-arene)tricarbonylchromium complexes. Perfluoroalkyl anions generated from Me3SiRF and a fluoride ion source [Me4N]F exclusively attack the arene ligand under mild conditions. The formed negatively charged analogs of Meisenheimer adducts readily undergo a one-pot oxidation to perfluoroalkyl arenes.

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