23972-16-9Relevant academic research and scientific papers
Synthesis of new benzylic ethers of oximes derived from 1-phenyl- pyrazole compounds
Muri, Estela M. F.,Barreiro, Eliezer J.,Fraga, Carlos A. M.
, p. 1299 - 1321 (2007/10/03)
In the scope of a research program aiming at the synthesis and pharmacological evaluation of new antithrombotic agents via rational molecular design, we describe in this paper the synthesis of benzyl ethers of aryl-pyrazolic oxime derivatives. Ethers' (2a-2c) and (3a-3c) are derived from 4-formyl-1-N-phenylpyrazole (4) in good yield. Designed as interphenylenic analogues of the ridogrel (1), one expects these compounds to present dual properties, i.e., thromboxane A2 receptors antagonism and thromboxane synthetase inhibition.
