23979-41-1 Usage
Description
(R)-NAPROXEN, also known as (S)-naproxen, is a chiral nonsteroidal anti-inflammatory drug (NSAID) derived from the naphthalene class. It is an enantiomer of naproxen, which means it is a molecule that is a mirror image of the other but is not identical. (R)-NAPROXEN possesses anti-inflammatory properties and acts as a cyclooxygenase inhibitor, which helps in reducing pain, inflammation, and fever. It is an almost white crystalline powder in its chemical form.
Uses
Used in Pharmaceutical Industry:
(R)-NAPROXEN is used as an anti-inflammatory agent for the treatment of various conditions such as arthritis, tendinitis, bursitis, and other musculoskeletal disorders. It works by inhibiting the cyclooxygenase enzyme, which is responsible for the production of prostaglandins that cause inflammation, pain, and fever.
Used in Pain Management:
(R)-NAPROXEN is used as a pain reliever for mild to moderate pain, including menstrual cramps, dental pain, and headaches. Its anti-inflammatory and analgesic properties make it an effective option for managing pain and discomfort.
Used in Cyclooxygenase Inhibition:
(R)-NAPROXEN is used as a cyclooxygenase inhibitor for the prevention of blood clot formation and the reduction of inflammation. This application is particularly useful in the management of conditions that involve excessive inflammation, such as rheumatoid arthritis and osteoarthritis.
Check Digit Verification of cas no
The CAS Registry Mumber 23979-41-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,9,7 and 9 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 23979-41:
(7*2)+(6*3)+(5*9)+(4*7)+(3*9)+(2*4)+(1*1)=141
141 % 10 = 1
So 23979-41-1 is a valid CAS Registry Number.
InChI:InChI=1/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m1/s1
23979-41-1Relevant articles and documents
SYNTHESIS OF OPTICALLY ACTIVE 2-ARYLALKANOIC ACIDS BY THE USE OF 1,2-REARRANGEMENT OF THE ARYL GROUP
Tsuchihashi, Gen-ichi,Mitamura, Shuichi,Kitajima, Kouji,Kobayashi, Kumi
, p. 5427 - 5430 (1982)
A new route to the synthesis of optically active 2-arylalkanoic acids was accomplished by using stereospecific 1,2-rearrangement of the aryl group in chiral 1-aryl-2-sulfonyloxy-1-alkanone acetals.
Nickel-catalyzed asymmetric reductive cross-coupling of α-chloroesters with (hetero)aryl iodides
Cleary, Leah,DeLano, Travis J.,Dibrell, Sara E.,Lacker, Caitlin R.,Pancoast, Adam R.,Poremba, Kelsey E.,Reisman, Sarah E.,Sigman, Matthew S.
, p. 7758 - 7762 (2021/06/16)
An asymmetric reductive cross-coupling of α-chloroesters and (hetero)aryl iodides is reported. This nickel-catalyzed reaction proceeds with a chiral BiOX ligand under mild conditions, affording α-arylesters in good yields and enantioselectivities. The reaction is tolerant of a variety of functional groups, and the resulting products can be converted to pharmaceutically-relevant chiral building blocks. A multivariate linear regression model was developed to quantitatively relate the influence of the α-chloroester substrate and ligand on enantioselectivity.
Bidentate phosphine-phosphine oxide ligand and intermediate, preparation method and application thereof
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Paragraph 0431-0438, (2020/11/10)
The invention discloses a bidentate phosphine-phosphine oxide ligand and an intermediate, a preparation method and application thereof. The phosphine oxide compound is shown as a formula I and/or ent-I. The phosphine oxide compound is used as a metal ligand and is applied to Suzuki-Miyaura coupling reaction so that generation of self-coupled by-products is avoided, and an alpha-aryl carbonyl compound is obtained; and the dosages of the ligand and the metal catalyst are less.