30012-51-2

Basic information

• Product Name: NAPROXEN METHYL ESTER
• Synonyms: 2-(6-Methoxynaphthalene-2-yl)propanoic acid methyl ester;6-Methoxy-α-methylnaphthalene-2-acetic acid methyl ester;α-Methyl-6-methoxy-2-naphthaleneacetic acid methyl ester;Methyl 2-(6-methoxynaphthalen-2-yl)propanoate
• CAS NO: 30012-51-2
• Molecular Formula: C₁₅H₁₆O₃
• Molecular Weight: 244.29
• Mol File: 30012-51-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: NAPROXEN METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: NAPROXEN METHYL ESTER(30012-51-2)
• EPA Substance Registry System: NAPROXEN METHYL ESTER(30012-51-2)

Safety Data

• Hazardous Substances Data: 30012-51-2(Hazardous Substances Data)

Upstream product

• 23981-80-8 naproxen 
• 23981-48-8 methyl 6-methoxy-2-naphthylacetate 
• 616-38-6 carbonic acid dimethyl ester 
• 76145-94-3 1-(6'-methoxy-2'-naphthyl)-2-chloro-1-propanone 

Downstream Products

• 23981-80-8 naproxen 
• 22204-53-1 (2S)-2-(6-methoxy(2-naphthyl))propanoic acid 
• 81623-44-1 (R)-naproxen methyl ester 
• 26159-35-3 (S)-naproxen methyl ester 
• 23979-41-1 (R)-2-(6-methoxy-2-naphthyl)propionic acid 
• 37414-52-1 2-(6-methoxy-2-naphthyl)-propyl alcohol 
• 105937-62-0 methyl 2-hydroxy-2-(6-methoxynaphth-2-yl)propionate 
• 478389-23-0 N’-(4-diethylamino-2-hydroxybenzylidene)-2-(6-methoxynaphthyl)propane hydrazide 
• 478289-62-2 N’-(2-hydroxybenzylidene)-2-(6-methoxynaphthyl)propane hydrazide 
• 69337-85-5 2-(6-methoxynaphthalen-2-yl)-2-methylpropanoic acid 

Relevant articles and documents

Selective Mono-methylation of Arylacetonitriles and Methyl Arylacetates by Dimethyl Carbonate

Both arylacetonitriles and methyl arylacetates react with dimethyl carbonate (DMC) (20 molar excess) at 180 - 200 deg C in the presence of K2CO3 to produce monomethylated 2-arylpropionitriles and methyl 2-arylpropionates, respectively, with a selectivity >99.5percent.The reaction, with wide application, proceeds by DMC acting as a methoxycarbonylating agent towards the ArCH-X anion (X = CN, CO2Me) and as a methylating agent to ArC-(CO2Me)X.DMC also proved to be the best solvent for such reactions.

Oxidative decarboxylation of naproxen

The decarboxylation of naproxen (1H) and its salt (1-) was achieved by means of chemical [Ce(IV) or S2O8/2-] and electrochemical oxidation. The product patterns were compatible with mechanisms involving single-electron transfer from the pl-system or the carboxylate moiety. The results are discussed in connection with the involvement of electron-transfer processes in the reported phototoxicity of naproxen.