239804-62-7

Upstream product

• 98-51-1 4-tert-butyltoluene 
• 207737-25-5 5-tert-butyl-2-methyl-4-thiocyanatophenylamine 
• 85336-17-0 5-tert-butyl-2-methylaniline 
• 62559-08-4 4-tert-butyl-2-nitrotoluene 
• 239804-61-6 Boc-protected 3-tert-butyl-6-methyl-4-thiocyanatoaniline 

Downstream Products

• 239804-63-8 Toluene-4-thiosulfonic acid S-(4-tert-butoxycarbonylamino-2-tert-butyl-5-methylphenyl) ester 
• 625447-26-9 toluene-4-thiosulfonic acid S-(4-acetylamino-2-tert-butyl-5-methyl-phenyl) ester 

Relevant academic research and scientific papers

HIV protease inhibitors

The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.

INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME

Compounds of formula (I) are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus.

Methods of making dihydropyrone HIV protease inhibitors

The present invention relates to methods of making dihydropyrone HIV inhibitors.

Synthesis of heterocyclic thiosulfonates

A simple synthesis of heterocyclic thiosulfonates containing indole, indoline, benzoimidazole, and quinoxaline rings is described. The synthesis of these thiosulfonates involves the preparation of the appropriately substituted thiols followed by sulfonyla

Nonpeptidic HIV protease inhibitors: 6-Alkyl-5, 6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2-t-butyl, 5-methylphenyl thio) moiety: Antiviral activities and pharmacokinetic properties

Dihydropyran-2-ones possessing amino and carboxamide functionalities on 3-SPh (2-tert-butyl, 5-methyl) ring were synthesized and evaluated for their antiviral activities. Both the enantiomers of inhibitor 15 were synthesized. The in vitro resistance profi