239804-63-8Relevant academic research and scientific papers
Methods of making dihydropyrone HIV protease inhibitors
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, (2008/06/13)
The present invention relates to methods of making dihydropyrone HIV inhibitors.
Nonpeptidic HIV protease inhibitors: 6-Alkyl-5, 6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2-t-butyl, 5-methylphenyl thio) moiety: Antiviral activities and pharmacokinetic properties
Vara Prasad,Boyer, Fred E.,Domagala, John M.,Ellsworth, Edmund L.,Gajda, Christopher,Hagen, Susan E.,Markoski, Larry J.,Tait, Bradley D.,Lunney, Elizabeth A.,Tummino, Peter J.,Ferguson, Donna,Holler, Tod,Hupe, Donald,Nouhan, Carolyn,Gracheck, Stephen J.,VanderRoest, Steven,Saunders, James,Iyer, Krishna,Sinz, Michael,Brodfuehrer, Joanne
, p. 1481 - 1486 (2007/10/03)
Dihydropyran-2-ones possessing amino and carboxamide functionalities on 3-SPh (2-tert-butyl, 5-methyl) ring were synthesized and evaluated for their antiviral activities. Both the enantiomers of inhibitor 15 were synthesized. The in vitro resistance profi
