23981-22-8

Basic information

• Product Name: 5-chloro-2-quinolone
• Synonyms: 5-chloro-2-quinolone;5-Chloroquinolin-2(1H)-one;5-Chloro-2(1H)-quinolinone
• CAS NO: 23981-22-8
• Molecular Formula: C₉H₆ClNO
• Molecular Weight: 179.60304
• Mol File: 23981-22-8.mol

Chemical Properties

• Melting Point: 288-289 °C(Solv: methanol (67-56-1))
• Boiling Point: 372.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.339±0.06 g/cm3(Predicted)
• PKA: 10.89±0.70(Predicted)
• CAS DataBase Reference: 5-chloro-2-quinolone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-quinolone(23981-22-8)
• EPA Substance Registry System: 5-chloro-2-quinolone(23981-22-8)

Safety Data

• Hazardous Substances Data: 23981-22-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-chloro-2-quinolone is used as an active pharmaceutical ingredient for its potential antibacterial and antifungal properties. It is being studied for its role in the development of new drugs that can combat resistant strains of bacteria and fungi, thereby addressing the growing need for novel antimicrobial agents.
Used in Medicinal Chemistry Research:
5-chloro-2-quinolone serves as a key intermediate in the synthesis of various biologically active compounds. It is used as a building block in the design and development of new pharmaceuticals, contributing to the advancement of medicinal chemistry.
Used in Academic Research:
In the field of pharmacology, 5-chloro-2-quinolone is used as a research tool to study its mechanism of action and potential interactions with biological targets. This research aids in understanding the compound's therapeutic potential and contributes to the development of more effective treatments.

Upstream product

• 445041-60-1 (E)-N-(3-chlorophenyl)-3-ethoxypropenamide 
• 1772-43-6 2,4,4-trimethyl oxazoline 
• 83-38-5 2,6-dichlorobenzaldehyde 

Downstream Products

• 68050-37-3 2-amino-5-chloroquinoline 
• 59412-12-3 2,5-dichloroquinoline 

Relevant articles and documents

Molecular recognition via triplex formation of mixed purine/pyrimidine DNA sequences using oligoTRIPs

Stable DNA triple-helical structures are normally restricted to homopurine sequences. We have described a system of four heterocyclic bases (TRIPsides) that, when incorporated into oligomers (oligoTRIPs), can recognize and bind in the major groove to any

2-(4-Alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists

With the aim of identifying structurally novel, centrally acting histamine H3 antagonists, a series of 2-(4-alkylpiperazin-1-yl)quinolines was prepared. Systematic variation of the substituents led to highly potent histamine H3 antagonists with low polar surface area and appropriate log P for blood-brain barrier penetration.

Dihydropyridazinones, pyridazinones and related compounds as fungicides

This invention relates to substituted dihydropyridazinones, pyridazinones and related compounds, of the formula STR1 wherein A, Q, D and R1 are as defined within, compositions containing these compounds and methods of controlling agricultural and mammalian fungal diseases.

Carbostyril derivatives used as coccidiostats

Carbostyril derivatives useful as coccidiostats are prepared by reacting an ortho-halo benzaldehyde with a 2-alkyl-2-oxazoline, then heating at above about 200° C thereby forming the carbostyril.