5-chloro-2-quinolone

Base Information

• Chemical Name: 5-chloro-2-quinolone
• CAS No.: 23981-22-8
• Molecular Formula: C9H6ClNO
• Molecular Weight: 179.60300
• Mol file: 23981-22-8.mol

Synonyms:5-Chlor-2(1H)-chinolon;5-Chloro-2(1H)-quinolinone;5-chlorocarbostyril;5-chloro-2-quinolinone;5-chloroquinolin-2(1H)-one;

Chemical Property of 5-chloro-2-quinolone

Chemical Property:

• Melting Point: 288-289 °C(Solv: methanol (67-56-1))
• Boiling Point: 372.6±42.0 °C(Predicted)
• PKA: 10.89±0.70(Predicted)
• PSA: 32.86000
• Density: 1.339±0.06 g/cm3(Predicted)
• LogP: 2.18150

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Chloroquinolin-2(1H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-chloro-2-quinolone

There total 5 articles about 5-chloro-2-quinolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2,4,4-trimethyl oxazoline (1772-43-6) + 2,6-dichlorobenzaldehyde (83-38-5) → 5-chloro-2-quinolone (23981-22-8)

Guidance literature:

With potassium hydrogensulfate; In 1-methyl-pyrrolidin-2-one; xylene; at 180 - 240 ℃; for 2.5h;

DOI:10.1021/ja0530218

Reference yield:

(E)-N-(3-chlorophenyl)-3-ethoxypropenamide (445041-60-1) → 7-chloroquinolin-2(1H)-one (22614-72-8) + 5-chloro-2-quinolone (23981-22-8)

Guidance literature:

With sulfuric acid; at 20 ℃; for 1.5h;

DOI:10.1021/jm040873u

Reference yield:

→ 5-chloro-quinolin-2-ol (23981-22-8)

Guidance literature:

With ethanol;

upstream raw materials:

(E)-N-(3-chlorophenyl)-3-ethoxypropenamide

2,4,4-trimethyl oxazoline

2,6-dichlorobenzaldehyde

Downstream raw materials:

2-amino-5-chloroquinoline

2,5-dichloroquinoline