23982-80-1

Upstream product

• 100-44-7 benzyl chloride 
• 1456-19-5 2-styryl-1H-benzo[d]imidazole 
• 100-52-7 benzaldehyde 
• 5805-83-4 1-benzyl-2-methylbenzimidazole 
• 615-15-6 2-Methyl-1H-benzimidazole 
• 95-54-5 1,2-diamino-benzene 
• 621-82-9 Cinnamic acid 

Relevant academic research and scientific papers

Green syntheses of n-alkyl-2-styrylbenzimidazoles

Simple and green methodologies for the syntheses of 2-styrylbenzimidazoles (3a-c) and its N-alkyl derivatives (7a-i) have been developed. o-Phenylenediamine (1) was condensed with cinnamic acids (2a-c) resulting in 2-styrylbenzimidazoles (3a-c) using glycerol as a green and efficient solvent. 3 were also prepared alternatively by the condensation of 2-methylbenzimidazole (4) with benzaldehydes (5a-c) using glycerol as solvent. 2-Styrylbenzimidazoles (3a-c) and 2-methylbenzimidazole (4) were alkylated independently to obtain N-alkyl- 2-styrylbenzimidazole (7a-i) and N-alkyl-2-methylbenzimidazole (6a-c), respectively using DMS/DES/PhCH2Cl applying green methods such as simple physical grinding of reactants in solid phase, treating reactants in PEG-600 as a solvent in solution phase and using microwave irradiation of reactants respectively. Compounds 7a-i could also be prepared, alternatively, by heating 6a-c with 5a-c in glycerol at 180 °C for 3-4 h.

Synthesis and antiviral activities of N-substituted-2-substituted- benzimidazole derivatives

Two series of N-substituted-2-substituted benzimidazole derivatives, viz. 1-benzyl-2-substituted benzimidazole 8-14 and 1-(p-chlorophenyl)-2-substituted benzimidazole 15-21 have been synthesized and tested for their antiviral activities. These compounds have been screened for Tobacco mosaic viruses and Sunhemp rosette viruses and show significant activities.