23999-44-2Relevant academic research and scientific papers
Visible-Light-Promoted Cascade Alkene Trifluoromethylation and Dearomatization of Indole Derivatives via Intermolecular Charge Transfer
Zhu, Min,Zhou, Kai,Zhang, Xiao,You, Shu-Li
, p. 4379 - 4383 (2018)
An intramolecular dearomatization of indole derivatives has been developed via an electron donor-acceptor complex formed between indole derivatives and Umemoto's reagent. Without the requirement of any catalyst and additive, diverse trifluoromethyl-substi
I2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines
Li, Yazhou,Liang, Xuewu,Liu, Hong,Liu, Qi,Liu, Xuyi,Wei, Xiaohui,Zhou, Yu
, p. 9165 - 9171 (2021/11/23)
The spiroindolenine framework is a privileged heterocyclic motif and is widely present in numerous indole alkaloids. Herein, we develop a metal-free and environmentally friendly approach for the intramolecular cascade cyclization and dearomatization of indole derivatives to selectively afford iodinated and vinylic spiroindolenines by a substrate-controlled strategy. Simple operation, mild conditions, and high yield make this strategy a green and attractive pathway to construct functionalizable spiroindolenine scaffolds, which could be converted into diverse useful spiroindolenine derivatives.
