4660-96-2

Basic information

• Product Name: N,N-dimethyl-1-(2-phenyl-1H-indol-3-yl)methanamine
• Synonyms: 1H-indole-3-methanamine, N,N-dimethyl-2-phenyl-
• CAS NO: 4660-96-2
• Molecular Formula: C₁₇H₁₈N₂
• Molecular Weight: 250.3382
• Mol File: 4660-96-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 425.7°C at 760 mmHg
• Flash Point: 211.3°C
• Density: 1.118g/cm³
• Vapor Pressure: 1.88E-07mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: N,N-dimethyl-1-(2-phenyl-1H-indol-3-yl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-1-(2-phenyl-1H-indol-3-yl)methanamine(4660-96-2)
• EPA Substance Registry System: N,N-dimethyl-1-(2-phenyl-1H-indol-3-yl)methanamine(4660-96-2)

Safety Data

• Hazardous Substances Data: 4660-96-2(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 948-65-2 2-phenyl-indole 
• 506-59-2 N,N-dimethylammonium chloride 
• 5379-79-3 N-(dimethylaminomethyl)indole 
• 591-50-4 iodobenzene 
• 124-40-3 dimethyl amine 

Downstream Products

• 25365-71-3 2-phenyl-1H-indol-3-carboxaldehyde 
• 4662-03-7 2-phenylindole-3-acetic acid 
• 23999-44-2 (2-phenyl-indol-3-ylmethyl)-malonic acid diethyl ester 

Relevant articles and documents

I2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines

The spiroindolenine framework is a privileged heterocyclic motif and is widely present in numerous indole alkaloids. Herein, we develop a metal-free and environmentally friendly approach for the intramolecular cascade cyclization and dearomatization of indole derivatives to selectively afford iodinated and vinylic spiroindolenines by a substrate-controlled strategy. Simple operation, mild conditions, and high yield make this strategy a green and attractive pathway to construct functionalizable spiroindolenine scaffolds, which could be converted into diverse useful spiroindolenine derivatives.

Visible-light-induced cascade dearomatization cyclization between alkynes and indole-derived bromides: A facile strategy to synthesize spiroindolenines

A visible-light-initiated intermolecular dearomatization cyclization cascade reaction between alkynes and indole-derived bromides has been explored. This transformation exhibits a wide substrate scope and significant functional group tolerance, providing an efficient way to access a variety of spiroindolenines under mild conditions. This journal is

A convenient metal-free reagent for the generation and capture of trifluoromethanethiol

O-Octadecyl-S-trifluorothiolcarbonate is a cheap and storable crystalline source of trifluoromethanethiol that can be prepared in two steps on a multigram scale from trifluoroacetic anhydride and sodium O-octadecyl-dithiocarbonate (xanthate). It reacts directly with gramines or with α-bromoketones and -esters in the presence of KF and pyrrolidine to give the corresponding trifluoromethyl sulfides in generally high yield.