24010-80-8

Basic information

• Product Name: 1-cyano-2-ethylguanidine
• CAS NO: 24010-80-8
• Molecular Formula: C₄H₈N₄
• Molecular Weight: 112.1331
• Mol File: 24010-80-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 199.8°C at 760 mmHg
• Flash Point: 74.6°C
• Density: 1.13g/cm³
• Vapor Pressure: 0.336mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: 1-cyano-2-ethylguanidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyano-2-ethylguanidine(24010-80-8)
• EPA Substance Registry System: 1-cyano-2-ethylguanidine(24010-80-8)

Safety Data

• Hazardous Substances Data: 24010-80-8(Hazardous Substances Data)

Usage

Guanidine derivative

It is derived from the guanidine structure, which is a common organic compound containing a nitrogen atom bonded to two carbon atoms.

Cyano group

The compound contains a cyano group (CN), which is a carbon atom triple-bonded to a nitrogen atom, providing the molecule with a strong electron-withdrawing property.

Ethyl group

1-Cyano-2-ethylguanidine also contains an ethyl group (C2H5), which is a two-carbon chain with a hydrogen atom and a methyl group attached to the carbons.

Primary use as a catalyst

This compound is mainly used as a catalyst in various chemical reactions, particularly in the production of polymers and resins.

Pharmaceutical intermediate potential

1-Cyano-2-ethylguanidine is being studied for its potential use as a pharmaceutical intermediate, which could lead to the development of new drugs and medications.

Hazardous substance classification

It is classified as a hazardous substance due to its potential health risks, such as skin and eye irritation, and harmful effects if ingested or inhaled.

Safety precautions

Proper safety measures should be taken when working with 1-cyano-2-ethylguanidine, including wearing appropriate personal protective equipment (PPE) and handling the compound in a well-ventilated area.

Upstream product

• 557-66-4 ethanamine hydrochloride 
• 1934-75-4 sodium dicyanamide 
• 5848-25-9 N-cyano-N'-ethyl-S-methylisothiourea 

Downstream Products

• 403603-30-5 N-[6-chloro-4-(2-nitrophenyl)quinazolin-2-yl]-N'-ethylguanidinium p-toluenesulfonate 
• 106592-54-5 3,5-diethyl-2-imino-4,6-dioxo-5-phenyl-tetrahydro-pyrimidine-1-carbonitrile 

Relevant articles and documents

In Vitro and in Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas

A newly validated target for tuberculosis treatment is phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. The structure-activity relat

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease

One of the main obstacles toward the discovery of effective anti-Alzheimer drugs is the multifactorial nature of its etiopathology. Therefore, the use of multitarget-directed ligands has emerged as particularly suitable. Such ligands, able to modulate different neurodegenerative pathways, for example, amyloid and tau cascades, as well as cognitive and neurogenic functions, are fostered to come. In this respect, we report herein on the first class of BACE-1/GSK-3β dual inhibitors based on a 3,4-dihydro-1,3,5-triazin-2(1H)-one skeleton, whose hit compound 1 showed interesting properties in a preliminary investigation. Notably, compound 2, endowed with well-balanced potencies against the two isolated enzymes (IC50 of 16 and 7 μM against BACE-1 and GSK-3β, respectively), displayed effective neuroprotective and neurogenic activities and no neurotoxicity in cell-based assays. It also showed good brain permeability in a pharmacokinetic assessment in mice. Overall, triazinone derivatives, thanks to the simultaneous modulation of multiple points of the diseased network, might emerge as suitable candidates to be tested in in vivo Alzheimer's disease models.

Synthesis of novel 4,6-di(substituted)amino- 1,2-dihydro-1,3,5-triazine derivatives as topical antiseptic agents

A series of novel 4,6-di(substituted)arnino-1,2-dihydro-1,3,5- triazine derivatives designed to have ClogP of 5.1-7.5 was synthesized and evaluated for their antiseptic properties by MIC and MBC tests against Gram-positive and Gram-negative bacteria, incl