2403-55-6

Usage

InChI:InChI=1/C8H15NO/c1-8(2)7-9-3-5-10-6-4-9/h7H,3-6H2,1-2H3

Upstream product

• 110-91-8 morpholine 
• 78-82-0 Isobutyronitrile 
• 41274-76-4 3,3-dimethyl-2-morpholin-4-yl-4-phenyl-cyclobutane-1,1-dicarbonitrile 

Downstream Products

• 10315-98-7 N-isobutylmorpholine 
• 28487-22-1 4-(2,2-dimethyl-4-pyridin-4-yl-cyclobutyl)-morpholine 
• 54608-70-7 6,6-dimethyl-7-morpholin-4-yl-3-phenyl-3-aza-bicyclo[3.2.0]heptane-2,4-dione 
• 41274-87-7 2,2,6,6-tetramethyl-7-morpholin-4-yl-5-phenyl-6,7-dihydro-5H-pyrano[2,3-d][1,3]dioxin-4-one 
• 41274-88-8 2,2,6,6-tetramethyl-7-morpholin-4-yl-5-(4-nitro-phenyl)-6,7-dihydro-5H-pyrano[2,3-d][1,3]dioxin-4-one 
• 93719-49-4 4-[N-(4-chloro-benzenesulfonyl)-isobutyrimidoyl]-morpholine 
• 39655-70-4 2-(3,3-dimethyl-4-morpholin-4-yl-2,5-diphenyl-cyclopenta-1,4-dienyl)-1-phenyl-butane-1,3-dione 
• 39655-68-0 3-(3,3-dimethyl-4-morpholin-4-yl-2,5-diphenyl-cyclopenta-1,4-dienyl)-pentan-2,4-dione 
• 33959-48-7 5-cyclohexylimino-1-heptafluoropropyl-3,3-dimethyl-4-morpholin-4-yl-pyrrolidin-2-one 
• 33959-49-8 5-cyclohexylimino-3,3-dimethyl-4-morpholin-4-yl-1-(2,2,2-trifluoro-1-trifluoromethyl-ethyl)-pyrrolidin-2-one 
• 34050-98-1 5-cyclohexylimino-3,3-dimethyl-4-morpholin-4-yl-1-(2,2,2-trifluoro-1,1-bis-trifluoromethyl-ethyl)-pyrrolidin-2-one 
• 49651-36-7 2,4,4-trimethyl-3-morpholino-2-vinylcyclobutanone 
• 49651-35-6 2,6,6-trimethyl-5-morpholino-cyclohex-2-enone 
• 69805-65-8 N-tert-butyl-3-methyl-2-morpholin-4-yl-butyramide 

Relevant academic research and scientific papers

Colloid and nanosized catalysts in organic synthesis: XIV. Reductive amination and amidation of carbonitriles catalyzed by nickel nanoparticles

Hydrogenation of carbonitriles catalyzed by nickel nanoparticles in the presence of primary amines led to the predominant formation of unsymmetrical secondary amines. In the presence of secondary amines hydrogenation of nitrites provided enamines as main products. Hydrogenation of nitriles in the presence of formamide or acetamide afforded formyl or acetyl derivatives of primary amines.

Electrophilicity parameters for benzylidenemalononitriles

Kinetics of the reactions of stabilized carbanions (derived from nitroethane, diethyl malonate, ethyl cyanoacetate, ethyl acetoacetate, acetyl acetone) with benzylidenemalononitriles have been determined in dimethyl sulfoxide solution at 20 °C. The second-order rate constants are employed to determine the electrophilicity parameters E of the benzylidenemalononitriles according to the correlation equation log k (20 °C) = s(E + N). Comparison with literature data shows that this equation allows the semiquantitative prediction of the reactivities of benzylidenemalononitriles toward a wide variety of nucleophiles, including carbanions, enamines, amines, water, and hydroxide.