917-93-1Relevant articles and documents
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Lorenzini,Walling
, p. 4008 (1967)
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PROCESS FOR THE PREPARATION OF 2,2-DIMETHYLPIPERAZINE
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Page/Page column 10; 11; 12, (2019/10/29)
This invention relates to a novel chemical process for the synthesis of 2,2-dimethylpiperazine and the further transformation of 2,2-dimethylpiperazine into ferf-butyl-3,3-dimethylpiperazine-l- carboxylate-hemi-DL-tartrate.
INHIBITORS OF BETA-SECRETASE
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Paragraph 0199-0200, (2014/03/24)
The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.