24048-74-6 Usage
Uses
Used in Medicinal Chemistry:
6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBALDEHYDE is used as a building block for the synthesis of biologically active molecules. Its unique chemical structure allows it to be incorporated into various drug candidates, potentially leading to the discovery of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBALDEHYDE serves as a reagent or intermediate for the preparation of various other compounds. Its aldehyde functional group can be utilized in a range of chemical reactions, enabling the synthesis of diverse organic molecules for various applications.
Used in Pharmaceutical Development:
6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBALDEHYDE is used in the development of pharmaceuticals due to its potential to contribute to the creation of new drugs. Its incorporation into drug candidates can enhance their biological activity and therapeutic potential, making it an important component in the advancement of medicinal chemistry.
Used in Fine Chemicals Production:
6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBALDEHYDE is also utilized in the production of fine chemicals, where its unique properties can be harnessed to create high-quality specialty chemicals for various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 24048-74-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,0,4 and 8 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 24048-74:
(7*2)+(6*4)+(5*0)+(4*4)+(3*8)+(2*7)+(1*4)=96
96 % 10 = 6
So 24048-74-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H6N2O3/c1-3-4(2-9)5(10)8-6(11)7-3/h2H,1H3,(H2,7,8,10,11)
24048-74-6Relevant academic research and scientific papers
Total Synthesis of the Antibiotic Sparsomycin, a Modified Uracil Amino Acid Monoxodithioacetal
Ottenheijm, Harry C.J.,Liskamp, Rob M.J.,Nispen, Simon P.J.M. van,Boots, Hans A.,Tijhuis, Marian W.
, p. 3273 - 3283 (2007/10/02)
The total syntheses of sparsomycin (1), a naturally occurring antibiotic and antitumor substance, and its three stereomers 65-67 are described for the first time.In a convergent approach, the carboxylic acid 2 and the amine 3 were synthesized followed by amide formation (Scheme I).The acid 2 was prepared (23percent yield) from 6-methyluracil (12) by coupling the aldehyde 19 with the phosphorane 20 (Scheme III).The synthesis of the amine 3, especially challenging because of the monoxodithioacetal moiety, was accomplished by the reaction of a cysteine α-halo sulfoxide derivative 8 with sodium methylmercaptide (Scheme II, route B).Alternatively, oxidation of the dithioacetals 23-26 was unsatisfactory, yielding predominantly the undesired regioisomers 27B-30B (Table I).Procedures are given for the preparation and separation of the α-halo sulfoxide diastereomers 33,35, 36-41, and 52-54.By use of these procedures, the amino alcohol monoxodithioacetals 3 and 60 were prepared in five steps (40percent yield) from the D-cystine derivative 59 having the SC chirality of sparsomycin (Scheme VII).Finally, sparsomycin (1) and the SC diastereomer 67 were prepared (40percent yield) by mixed anhydride coupling of 2 with 3 and 60, respectively (Schemes I and X).In addition, syntheses of the RC enantiomer 65 and corresponding diastereomer 66 are described (Scheme IX).The CD spectra of 1 and its three stereomers are also discussed.
