5900-40-3

Usage

Uses

Used in Pharmaceutical Synthesis:
6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBONITRILE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Production:
In the agrochemical industry, 6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBONITRILE is utilized as a building block for the creation of agrochemicals. Its role in this sector is crucial for the development of effective and innovative products that address agricultural challenges.
Used in Organic Synthesis Research:
6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBONITRILE is employed as a research compound in organic synthesis. Its properties and potential applications are of interest to chemists and researchers, who are continually exploring its capabilities and possible uses in various chemical reactions and processes.
The diverse applications of 6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBONITRILE highlight its importance in the fields of chemistry, pharmaceuticals, and agriculture. Its potential for further investigation and research underscores the need for ongoing exploration into its capabilities and contributions to these industries.

InChI:InChI=1/C6H5N3O2/c1-3-4(2-7)5(10)9-6(11)8-3/h1H3,(H2,8,9,10,11)

Upstream product

• 77747-66-1 N-carbamoyl-2-cyano-3-oxobutanamide 
• 24048-74-6 1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinecarbaldehyde 

Downstream Products

• 51622-67-4 5-carboxy-6-methyluracil 
• 101375-08-0 N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester 
• 101348-20-3 N-pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid 
• 101348-00-9 N-pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid 
• 101348-19-0 diethyl N-pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamate 

Relevant academic research and scientific papers

Synthesis of New N-Hydroxy-6-methyluracil-5-carboximidoyl Chloride Derivatives

N-Hydroxy-6-methyluracil-5-carboximidoyl chloride was synthesized for the first time, and its halogenation and reactions with amines (imidazole, aniline) were studied. The reaction of the title compound with sodium azide gave the corresponding N-hydroxyca

Chemical Properties of 6-Methyluracil-5-carbaldehyde Oxime

Oxidative chlorination of 6-methyluracil-5-carbaldehyde oxime in a two-phase system gave 7V-hydroxy-6-methyluracil-5-carboximidoyl chloride, and its bromination afforded ipso-substitution products, 5-bromo-6-methyluracil and 5,5-dibromo-6-hydroxy-6-methyl-5,6-dihydrouracil. The reaction of the title compound with acetic anhydride led to the formation of 6-methyluracil-5-carbonitrile or O-acetyl derivative, depending on the temperature. 7V-Hydroxy-6-methyluracyl-5-carboximidoyl chloride reacted with acetic acid at 100°C or with potassium iodide in boiling acetone to produce uracil-5-hydroxamic acid which was converted with high yields into the corresponding methyl ester and hydroximic acid amide. Quaternary ammonium salts were obtained by reactions of N-hydroxy-6-methyluracil-5-carboximidoyl chloride with pyridine and 1-methyl-1H-imidazole.

INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE

The present disclosure discloses compounds capable of modulating the activity of α- amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.

PREPARATION OF SUBSTITUTED 5-PYRIMIDINECARBONITRILES AND 1,3,5-TRIAZINES FROM ALKYL N-CYANOIMIDATES

Sodium methoxide induced the cyclization of alkyl N-cyanoimidates 1 with propanedinitrile affording the 5-pyrimidinecarbonitriles 2.The reaction of 1 with methyl cyanoaetate led to the methyl 3-propenoates 7 and the 2,4-dioxo-5-pyrimidinecarbonitrile 8.An analogous cyclization of 1 with cyanamide yielded the 1,3,5-triazines 10.