24058-92-2

Usage

Uses

Used in Pharmaceutical Industry:
1,5-Diphenyl-1H-[1,2,4]triazole-3-carboxylic acid is used as a key intermediate compound for the synthesis of heterocyclic inhibitors targeting the P2X3 receptor. These inhibitors have potential therapeutic applications in treating various types of pain, as well as genito-urinary, gastrointestinal, and respiratory disorders. The compound's ability to form heterocyclic structures allows for the development of novel and effective treatments for these conditions.

InChI:InChI=1/C15H11N3O2/c19-15(20)13-16-14(11-7-3-1-4-8-11)18(17-13)12-9-5-2-6-10-12/h1-10H,(H,19,20)/p-1

Upstream product

• 84797-84-2 2-phenyl-4-phenylhydrazono-2-oxazolin-5-one 
• 100-52-7 benzaldehyde 
• 178168-62-2 amino-(N'-phenyl-hydrazono)-acetonitrile 
• 2684-02-8 benzenediazonium 
• 1199-01-5 2-phenylazlactone 
• 89060-64-0 1,5-diphenyl-3-methoxycarbonal-1,2,4-triazole 

Downstream Products

• 89060-64-0 1,5-diphenyl-3-methoxycarbonal-1,2,4-triazole 
• 24685-75-4 1-phenyl-5-phenyl-1H-1,2,4-triazole 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of glycolamide, glycinamide, and β-amino carbonyl 1,2,4-triazole derivatives as DPP-4 inhibitors

Through modification of the skeleton of Sitagliptin and Vildagliptin, we successfully synthesized and built-up four series of 1,2,4-triazole derivatives, containing N,O-disubstituted glycolamide, N,N′-disubstituted glycinamide, β-amino ester, and β-amino

Transmission of substituent effects via 1,2,4-triazole ring residue

The ionization constants of a series of 5-phenyl-3-substituted phenyl-1,2,4-triazole-3-carboxylic acids (2a-j), prepared by the base catalysed rearrangement of 2-phenyl-4-arylazo-5-oxazolones (1a-j), and the rate of alkaline hydrolysis of the correspondin