24685-75-4

Upstream product

• 24058-92-2 1,5-diphenyl-1H-[1,2,4]triazole-3-carboxylic acid 
• 4252-31-7 N-formylbenzamide 
• 100-63-0 phenylhydrazine 
• 100-47-0 benzonitrile 
• 2684-02-8 benzenediazonium 
• 13423-60-4 1-phenyl-1H-1,2,4-triazole 
• 108-86-1 bromobenzene 
• 50-00-0 formaldehyd 
• 100-52-7 benzaldehyde 
• 100-51-6 benzyl alcohol 
• 84797-84-2 2-phenyl-4-phenylhydrazono-2-oxazolin-5-one 
• 1199-01-5 2-phenylazlactone 
• 59-88-1 phenylhydrazine hydrochloride 

Relevant academic research and scientific papers

A Multicomponent Electrosynthesis of 1,5-Disubstituted and 1-Aryl 1,2,4-Triazoles

A novel electrochemical route has been developed for the synthesis of 1,5-disubstituted and 1-aryl 1,2,4-triazoles from aryl hydrazines, paraformaldehyde, NH4OAc, and alcohols. In this multicomponent reaction system, alcohols act as solvents as well as reactants and NH4OAc is used as the nitrogen source. With the assistance of reactive iodide radical or I2 and NH3 electrogenerated in situ, this process could effectively avoid the use of strong oxidants and transition-metal catalysts and be smoothly carried out at room temperature to give a wide array of 1,2,4-triazole derivatives in good to high yields. Preliminary studies reveal that the reaction mechanism involves a radical process.

Regioselective copper-diamine-catalyzed C-H arylation of 1,2,4-triazole ring with aryl bromides

A convenient methodology for the regioselective C-H arylation of 1,2,4-triazole ring was developed. Using a benchtop stable Cu-diamine catalyst system, C-H functionalization of a simple 1,2,4-triazole substrate with various aryl bromides was regioselectively accomplished at the C5 position of the triazole ring.

C-H bonds as ubiquitous functionality: Preparation of multiple regioisomers of arylated 1,2,4-triazoles via C-H arylation

We describe a general approach for the synthesis of complex aryl 1,2,4-triazoles. The electronic character of the C-H bonds and the triazole ring allows for the regioselective C-H arylation of 1-alkyl- and 4-alkyltriazoles under catalytic conditions. We have also developed the SEM and THP switch as well as trans-N-alkylation, which enable sequential arylation of the triazole ring to prepare 3,5-diaryltriazoles. This new strategy provides rapid access to a variety of arylated 1,2,4-triazoles and well complements existing cyclization methods.

About Nitrile-Formamide-Chloride-Adducts. IX - Synthesis of 1,3- or 1,5-Disubstituted 1,2,4-Triazoles by the Reaction of Nitrile-Formamide Chloride-Adducts and their Products of Hydrolysis with Hydrazines

2-Aza-3-chloro-2-propeniminium salts 5, which are easily available by the addition of formamide chlorides 1 to nitriles 2 react smoothly with hydrazines 9 giving rise to 1,3-disubstituted 1,2,4-triazoles 11.When the 2-aza-3-chloro-2-propeniminium salts 5

Substituted 1H-1,2,4-triazoles

This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibitin