2406-34-0

Basic information

• Product Name: CYCLOPENTAMETHYLENEDICHLOROSILANE
• Synonyms: 1,1-Dichloro-1-silacyclohexane;1,1-dichloro-silacyclohexan;CYCLOPENTAMETHYLENEDICHLOROSILANE;1,1-dichlorosilacyclohexane;1,1-dichlorosilinane
• CAS NO: 2406-34-0
• Molecular Formula: C₅H₁₀Cl₂Si
• Molecular Weight: 169.12
• EINECS: 219-301-5
• Mol File: 2406-34-0.mol

Chemical Properties

• Boiling Point: 172.1°Cat760mmHg
• Flash Point: 52.6°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 1.8mmHg at 25°C
• Refractive Index: 1.461
• CAS DataBase Reference: CYCLOPENTAMETHYLENEDICHLOROSILANE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOPENTAMETHYLENEDICHLOROSILANE(2406-34-0)
• EPA Substance Registry System: CYCLOPENTAMETHYLENEDICHLOROSILANE(2406-34-0)

Safety Data

• Hazardous Substances Data: 2406-34-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
CYCLOPENTAMETHYLENEDICHLOROSILANE is employed as a reagent in organic synthesis for its ability to participate in various chemical reactions, contributing to the formation of a wide range of organic compounds.
Used in Silicone and Organosilicon Compound Manufacturing:
In the manufacturing industry, CYCLOPENTAMETHYLENEDICHLOROSILANE is used as a key component in the production of silicones and other organosilicon compounds, which are known for their diverse applications in various sectors, including construction, electronics, and personal care products.
Used in Research Settings:
CYCLOPENTAMETHYLENEDICHLOROSILANE is also utilized in research environments for the development and study of new chemical processes and materials, given its unique reactivity and properties.

InChI:InChI=1/C5H10Cl2Si/c6-8(7)4-2-1-3-5-8/h1-5H2

Upstream product

• 23708-48-7 pentamethylenebis(magnesium bromide) 
• 18163-69-4 dichloro-pent-4-enyl-silane 
• 10026-04-7 tetrachlorosilane 
• 30090-51-8 4-penten-1-ylmagnesium chloride 
• 106702-37-8 dichloro-μ-1,5-pentanediylmagnesium 
• 111-24-0 1,5-dibromo-pentane 

Downstream Products

• 4040-74-8 1,1-dimethyl-1-silacyclohexane 
• 18002-79-4 1,1-diphenyl-silinane 
• 165-07-1 spiro[dibenzosilole-5,1'-silinane] 
• 18768-21-3 1,1-bis-biphenyl-2-yl-silinane 
• 15303-35-2 4-Pentenyl-(1)-trimethoxy-silan 
• 5994-94-5 7,8,15,16-tetraphenyl-7,8,15,16-tetraaza-6,9-disila-dispiro[5.2.5.2]hexadecane 
• 2504-62-3 5-Trichlorsilyl-1-penten 
• 72810-13-0 1-(4-Chlorphenyl)-1-chlor-silacyclohexan 
• 781626-12-8 1-methoxy-1-(2,4,6-trimethoxyphenyl)-1-silacyclohexane 
• 781626-14-0 1-chloro-1-[1-(4-methoxyphenyl)vinyl]-1-silacyclohexane 
• 521059-17-6 rac-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-1-silacyclohexan-1-ol 
• 521059-16-5 {1-[2-dimethylamino-1-(4-methoxy-phenyl)-ethyl]-silinan-1-yl}-dimethyl-amine 
• 781626-13-9 1-[1-(4-methoxyphenyl)vinyl]-1-(2,4,6-trimethoxyphenyl)-1-silacyclohexane 
• 73942-32-2 1-(4-Chlorphenyl)-1-silacyclohexan-1-ol 

Relevant articles and documents

New polyunsaturated organosilicon dendrimers based on 1,1-diethynyl-and 1-vinyl-1-ethynylsilacycloalkanes

1,1-Dichloro-and 1-vinyl-1-chlorosilacyclanes were prepared by reactions of tetrachlorosilane or vinyltrichlorosilane with magnesium and 1,4-dibromobutane or 1,5-dibromopentane. The reactions of the products obtained with ethynylmagnesium bromide or bis(bromomagnesio)acetylene yield the corresponding ethynylsilacyclanes. Condensation of 1,1-diethynylsilacyclanes or bis(ethynylsilacyclopentyl)ethyne with an equimolar amount of ethylmagnesium bromide and methylbis(trimethylsilylethynyl)fluorosilane gave the corresponding highly unsaturated mono-and binuclear first-generation dendrimers with the cores formed by the silicon atoms incorporated in silacycloalkane fragments. The 1H, 13C, and 29Si NMR spectra of all the compounds obtained were studied. The key parameters and the chemical graph of the new dendrimers are presented. Nauka/Interperiodica 2006.

3-Silaazetidine: An Unexplored yet Versatile Organosilane Species for Ring Expansion toward Silaazacycles

Small-ring silacycles are important organosilane species in main-group chemistry and have found numerous applications in organic synthesis. 3-Silaazetidine, a unique small silacycle bearing silicon and nitrogen atoms, has not been adequately explored due to the lack of a general synthetic scheme and its sensitivity to air. Here, we describe that 3-silaazetidine can be easily prepared in situ from diverse air-stable precursors (RSO2NHCH2SiR12CH2Cl). 3-Silaazetidine shows excellent functional group tolerance in a palladium-catalyzed ring expansion reaction with terminal alkynes, giving 3-silatetrahydropyridines and diverse silaazacycle derivatives, which are promising ring frameworks for the discovery of Si-containing functional molecules.

A kind of preparation method of the midbody of entecavir, and intermediate

The invention discloses Entecavir intermediates and a preparation method thereof. The preparation method of an Entecavir intermediate represented by a formula IV or IV' shown in descriptions comprises the following step of enabling a compound V to be subjected to amino protecting group and hydroxyl protecting group removal reaction in the presence of protonic acid in a solvent. The preparation method disclosed by the invention has the advantages that raw materials are cheap and are easily obtained, reaction conditions are mild, side reactions are few, the yield is high, the pollution to the environment is little, and the intermediates are easily purified and separated, so that the preparation method is applicable to industrial production.

Entecavir intermediate and its preparation method

The invention discloses an entecavir intermediate and a preparation method thereof. A provided preparation method for an entecavir intermediate compound 10 comprises the following steps: performing reducing reaction on an ester compound 11 in an organic solvent under the effect of a reducing agent, so as to obtain the compound 10. A provided preparation method for an entecavir intermediate compound 11 comprises the following steps: reacting a compound 12 with a hydroxyl protection reagent in an organic solvent in the presence of an acid to add a hydroxyl protection group, so as to obtain the compound 11. The preparation methods are cheap and easily available in raw materials, mild in reaction conditions, relatively high in product yield, good in atom economy, friendly to environment, and suitable for industrialized production.

Hexacoordinate silacyclobutane dichelate complexes: Structure, properties, and ligand crossover

Hexacoordinate dichelate silacyclobutane complexes have been synthesized from dichlorosilacyclobutane and O-trimethylsilylated hydrazides by transsilylation. Like previously reported hexacoordinate silicon complexes, they readily and quantitatively undergo ligand exchange with other silicon compounds (XSiCl3 and differently substituted O-trimethylsilylated hydrazides), evidence that ionic dissociation does not play a significant role in the exchange mechanism. Germanium tetrachloride causes central-element exchange and formation of analogous hexacoordinate germanium complexes. Likewise, silicon tetrachloride replaces germanium from its hexacoordinate complexes, obeying certain selectivity constraints. When silicon complexes have strongly electron-withdrawing chelate-ring substituents (CF3 or CH2CN), GeCl4 causes, in addition to central-element exchange, also oxidative opening of the four-membered ring and addition of two chlorine atoms. Both chelate exchange and central-element exchange are shown to be dominated by monodentate ligand priorities.

1-(2-AMINO-1-PHENYL-ETHYL) 1- SILACYCLOHEXAN-1- OL DERIVATIVES AND USE THEREOF IN THE PREPARATION OF A MEDICAMENT

A compound selected from: (RS)-1-[2-methylamino-1-(4-methoxyphenyl)ethyl]-1-silacyclohexan-1-ol; (R)-1-[2-methylamino-1-(4-methoxyphenyl)ethyl]-1-silacyclohexan-1-ol; (S)-1-[2-methylamino-1-(4-methoxyphenyl)ethyl]-1-silacyclohexan-1-ol; (RS)-1-[2-amino-1-(4-methoxyphenyl)ethyl]-1-silacyclohexan-1-ol; (R)-1-[2-amino-1-(4-methoxyphenyl)ethyl]-1-silacyclohexan-1-ol (S)-1-[2-amino-1-(4-methoxyphenyl)ethyl]-1-silacyclohexan-1-ol; (RS)-1-[2-dimethylamino-1-(4-hydroxyphenyl)ethyl]-1-silacyclohexan-1-ol; (R)-1-[2-dimethylamino-1-(4-hydroxyphenyl)ethyl]-1-silacyclohexan-1-ol; (S)-1-[2-dimethylamino-1-(4-hydroxyphenyl)ethyl]-1-silacyclohexan-1-ol; (RS)- 1-[2-amino-1-(4-hydroxyphenyl)ethyl]-1-silacyclohexan-1-ol; (R)-1-[2-amino-1-(4-hydroxyphenyl)ethyl]-1-silacyclohexan-1-ol; (S)-1-[2-amino-1-(4-hydroxyphenyl)ethyl]-1-silacyclohexan-1-ol; (RS)- 1-[2-methylamino-1-(4-hydroxyphenyl)ethyl]-1-silacyclohexan-1-ol; (R)-1-[2-methylamino-1-(4-hydroxyphenyl)ethyl]-1-silacyclohexan-1-ol; (S)-1-[2-methylamino-1-(4-hydroxyphenyl)ethyl]-1-silacyclohexan-1-ol; (RS)-1-[2-dimethyl amino-1-(4-methoxyphenyl)ethyl]-1-silacyclohexan-1,4-diol; (R)-1-[2-dimethylamino-1-(4-methoxyphenyl)ethyl]-1-silacyclohexan-l,4-diol; and (S)-1-[2-dimethylamino-1-(4-methoxyphenyl)ethyl]-1-silacyclohexan-1,4-diol; or a pharmaceutically acceptable salt thereof or a prodrug form that is hydrolysable to a compound as defined above.

Macrocyclic polyether compounds

Macrocyclic polyether "crown" compounds of the formula EQU1 WHEREIN T is a C2 -C3 alkylene, A is EQU2 R being H or C1 -C18 alkyl, R2 and R3 being independently C1 -C18 alkyl, C2 -C4 alkenyl, or C6 -C14 aryl; Q and Z are independently 1,2-arylene (or saturated derivatives thereof) or substituted 1,2-arylene (or saturated derivatives thereof); a is 0, 1, 2, or 3; b is an integer from 3 to 20; y is 1 or zero; x1, x2, x3, and x4 are integers independently selected to give a 15-60 atom ring. Such crown compounds are generally useful in the formation of complexes with ionic metal compounds, thus making it possible to use certain chemical reagents in media wherein they are normally insoluble.