2407-87-6

Upstream product

• 86770-31-2 2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate 
• 122-51-0 orthoformic acid triethyl ester 
• 5430-79-5 ethyl 2-iodo-3,5-dimethylpyrrole-4-carboxylate 
• 5442-91-1 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 4-ethyl ester 
• 118-75-2 chloranil 
• 5442-92-2 2,4,2',4'-tetramethyl-1H,1'H-5,5'-methanediyl-bis-pyrrole-3-carboxylic acid diethyl ester 
• 2199-59-9 ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate 
• 50-00-0 formaldehyd 
• 56453-92-0 ethyl 5-bromo-2,4-dimethylpyrrole-3-carboxylate 
• 2199-51-1 2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 79-04-9 chloroacetyl chloride 
• 25907-30-6 ethyl 4-formyl-5-methyl-1H-pyrrole-2-carboxylate 
• 64-18-6 formic acid 

Downstream Products

• 14074-96-5 {Ni(C₁₉H₂₃N₂O₄)2} 
• 14564-48-8 {Co(C₁₉H₂₃N₂O₄)2} 
• 31188-33-7 Cadmium * 2 3.5.3'.5'-Tetramethyl-pyrromethen-(2.2')-dicarbonsaeure-(4.4')-diaethylester 
• 14653-46-4 {Cu(C₁₉H₂₃N₂O₄)2} 

Relevant academic research and scientific papers

Selective synthesis and utility of one tripyrrolic compound and its intermediates

Highly selective syntheses of tri(2,4-dimethyl-3-carbethoxypyrrolyl)- methane 8 and its dipyrrolic intermediate 6 and pyrrolic one 1 are described based on the successful correction of the wrong process for 1 in literature. Tripyrrolic compounds have attracted much attention recently and been developed in diverse fields. 1 was the key intermediate for some tyrosine kinase inhibitors, including newly-launched Sutent, and most recently we have found 6 was also synthetically useful in the synthesis of 11 that has been discovered as a novel histone deacetylases (HDAC) inhibitor with an IC 50 value of about 1 μM in our assessments and represents a promising lead for the development of more potent histone deacetylase inhibitors (HDACIs).