24071-98-5Relevant academic research and scientific papers
Remote ester group leads to efficient kinetic resolution of racemic aliphatic alcohols via asymmetric hydrogenation
Yang, Xiao-Hui,Wang, Ke,Zhu, Shou-Fei,Xie, Jian-Hua,Zhou, Qi-Lin
supporting information, p. 17426 - 17429 (2015/02/02)
A highly efficient method for kinetic resolution of racemic aliphatic alcohols without conversion of the hydroxyl group has been realized; the method involves hydrogenation mediated by a remote ester group and is catalyzed by a chiral iridium complex. This powerful, environmentally friendly method provides chiral δ-alkyl-δ-hydroxy esters and δ-alkyl-1,5-diols in good yields with high enantioselectivities even at extremely low catalyst loading (0.001 mol %).
Synthesis of γ-, δ-, and ε-lactams by asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)iminoesters
Guijarro, David,Pablo, Oscar,Yus, Miguel
, p. 3647 - 3654 (2013/05/22)
Highly enantiomerically enriched γ- and δ-lactams have been prepared by a simple and very efficient procedure that involves the asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)iminoesters followed by desulfinylation of the nitrogen atom and spo
Synthesis and studies of piperidinone, the major metabolite of a new antidepressant drug S 3344
Berthelot,Vaccher,Devergnies,Flourquet,Debaert
, p. 1525 - 1529 (2007/10/02)
The synthesis of 1-(4-fluorobenzyl)-6-isopropyl-2-piperidinone 7a, a major metabolite of a new antidepressant S 3344, is described and then substituted with various substituents. The 1H and 13C nmr provide information on their struct
