24085-07-2

Basic information

• Product Name: 1-(4-Acetyloxy)-3-((acetyloxy)methyl)phenyl)-2-bromoethanone
• Synonyms: 1-(4-Acetyloxy)-3-((acetyloxy)methyl)phenyl)-2-bromoethanone;4-Hydroxy-3-hydroxymethyl-bromoace-tophenone diacetate;4-Acetoxy-3-acetoxyMethyl-α-broMoacetophenone;2-AcetoxyMethyl-4-broMophenyl Acetate;2-BroMo-4'-hydroxy-3'-(hydroxyMethyl)acetophenone Diacetate;4-Hydroxy-3-Hydroxynethyl-A-Bromoacetophenone Diacetate;4-Acetoxy-3-acetoxymethyl-a-bromoacetophenone
• CAS NO: 24085-07-2
• Molecular Formula: C₁₃H₁₃BrO₅
• Molecular Weight: 329.14332
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 24085-07-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 428.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.465±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: Chloroform, Dichloromethane
• CAS DataBase Reference: 1-(4-Acetyloxy)-3-((acetyloxy)methyl)phenyl)-2-bromoethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Acetyloxy)-3-((acetyloxy)methyl)phenyl)-2-bromoethanone(24085-07-2)
• EPA Substance Registry System: 1-(4-Acetyloxy)-3-((acetyloxy)methyl)phenyl)-2-bromoethanone(24085-07-2)

Safety Data

• Hazardous Substances Data: 24085-07-2(Hazardous Substances Data)

Usage

Chemical Properties

Brown Oil

Upstream product

• 24085-06-1 4'-acetoxy-3'-(acetoxymethyl)acetophenone 
• 39235-58-0 4-hydroxy-3-hydroxymethylacetophenone 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 64092-10-0 N-benzylsalbutamone 
• 380414-69-7 (1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol 
• 380414-68-6 (1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanol 
• 380414-67-5 (1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanone 
• 102293-80-1 2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone 
• 135271-47-5 (R)-(-)-salmeterol 
• 62932-94-9 2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone 

Relevant articles and documents

Preparation method of salbutamol intermediate V hydrochloride

Salbutamol is a beta receptor stimulant. In the conventional preparation technology of salbutamol, reference listed drug technology is taken as the main research content; in the reference listed drugtechnology, p-Hydroxyacetophenone is taken as an initial

Preparation method of leverbuterol and its salt

The invention provides a method for cheap and effective preparation of leverbuterol in industry. The method consists of: taking protected 4-hydroxy-3-hydroxymethyl acetophenone as the raw material to react with bromine to generate acyl or alkyl protected 4-hydroxy-3-hydroxymethyl bromoacetophenone, under in the presence of (1R, 2S)-(+)-indanol as a catalyst, using borane to conduct chiral reduction on carbonyl in the structural formula to obtain R configuration acyl or alkyl protected 4-hydroxy-3-hydroxymethyl alpha bromo phenethyl alcohol, then carrying out reaction with tert-butylamine to generate acyl or alkyl protected 4-hydroxy-3-hydroxymethyl phenylaminoethanol, and finally removing the acyl protecting group to obtain leverbuterol free alkali, and letting the free alkali and acid form a salt. The finished product has optical purity up to 99.9%, and no other chiral resolution way is needed for purification.

Synthesis of the β2 Agonist (R)-Salmeterol Using a Sequence of Supported Reagents and Scavenging Agents

(Matrix Presented) The enantioselective synthesis of (R)-salmeterol has been achieved by using a sequence of supported reagents and sequestering agents. The saligenin core was installed by a regiospecific alkylation and a chiral auxiliary approach was employed to introduce the desired stereochemistry via a diastereoselective reduction.