62932-94-9

Basic information

• Product Name: 2-BROMO-1-[4-HYDROXY-3-(HYDROXYMETHYL)PHENYL]ETHAN-1-ONE
• Synonyms: 2-BROMO-1-[4-HYDROXY-3-(HYDROXYMETHYL)PHENYL]ETHAN-1-ONE;2-Bromo-4-hydroxy-3-(hydroxymethyl)acetophenone;Ethanone, 2-broMo-1-[4-hydroxy-3-(hydroxyMethyl)phenyl]-;2-broMo-1-(4-hydroxy-3-(hydroxyMethyl)phenyl)ethanone;2-broMo-1-[4-hydroxy-3-(hydroxy
• CAS NO: 62932-94-9
• Molecular Formula: C₉H₉BrO₃
• Molecular Weight: 245.07
• EINECS: 810-683-4
• Product Categories: Intermediate
• Mol File: 62932-94-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 349.4±11.0 °C(Predicted)
• Appearance: /
• Density: 1.674±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 7.69±0.20(Predicted)
• Stability: Not Stable in Solution
• CAS DataBase Reference: 2-BROMO-1-[4-HYDROXY-3-(HYDROXYMETHYL)PHENYL]ETHAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-[4-HYDROXY-3-(HYDROXYMETHYL)PHENYL]ETHAN-1-ONE(62932-94-9)
• EPA Substance Registry System: 2-BROMO-1-[4-HYDROXY-3-(HYDROXYMETHYL)PHENYL]ETHAN-1-ONE(62932-94-9)

Safety Data

• Hazardous Substances Data: 62932-94-9(Hazardous Substances Data)

Usage

Uses

2-Bromo-1-[4-hydroxy-3-(hydroxymethyl)phenyl]ethanone is a reagent used in the design of haptens for the screening of highly sensitive and specific monoclonial antibody to salbatamol.

Preparation

Obtained by treatment of its diacetate with 1 N hydrogen bromide in tetrahydrofuran at 75°.

InChI:InChI=1S/C9H9BrO3/c10-4-9(13)6-1-2-8(12)7(3-6)5-11/h1-3,11-12H,4-5H2

Synthetic route

5-(2-bromoacetyl)-2-hydroxybenzaldehyde (115787-50-3) → 2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9)

Conditions	Yield
Stage #1: 5-(2-bromoacetyl)-2-hydroxybenzaldehyde With propionic acid In tetrahydrofuran at 5 - 10℃; for 0.5h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran at 0 - 5℃; for 1h; Solvent; Reagent/catalyst;	94%
With sodium tetrahydroborate; acetic acid at 0 - 20℃; Inert atmosphere;	88%
With sodium tetrahydroborate; acetic acid at 8 - 20℃;	85%
With sodium tetrahydroborate; acetic acid at 10℃; for 1h;	85%
With sodium tetrahydroborate; acetic acid at 25℃; for 1h;	80%

3'-acetoxymethyl-4'-acetoxy-2-bromoacetophenone (24085-07-2) → 2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9)

Conditions	Yield
With hydrogen bromide In tetrahydrofuran at 75℃;
With hydrogen bromide In methanol; water
With hydrogen bromide In methanol; water

4'-acetoxy-3'-(acetoxymethyl)acetophenone (24085-06-1) → 2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: polyvinylpyridinium bromide perbromide resin / CH2Cl2 2: 1N HBr / tetrahydrofuran / 75 °C View Scheme

4-Hydroxyacetophenone (99-93-4) → 2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: resin-bound piperazinomethylpolystyrene / H2O; tetrahydrofuran 1.2: 14 percent / pTSA / toluene / 110 °C 2.1: polyvinylpyridinium bromide perbromide resin / CH2Cl2 3.1: 1N HBr / tetrahydrofuran / 75 °C View Scheme

salicylaldehyde (90-02-8) → 2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane / 15 h / Reflux 2: sodium tetrahydroborate; acetic acid / 1 h / 10 °C View Scheme
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride / dichloromethane / 0.5 h / 50 °C 1.2: 12 h / 40 °C 2.1: sodium tetrahydroborate; acetic acid / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride / dichloromethane / 0.5 h / 10 - 30 °C 1.2: 24 h / 35 °C 2.1: acetic acid; sodium tetrahydroborate / 1 h / 25 °C View Scheme

2-Methoxypropene (116-11-0) + 2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → 2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone (102293-80-1)

Conditions	Yield
With toluene-4-sulfonic acid In dichloromethane at 0℃; for 0.666667h;	100%
With resin-SO3H In dichloromethane
With toluene-4-sulfonic acid In tetrahydrofuran at -10 - 10℃; for 1h;

2,2-dimethoxy-propane (77-76-9) + 2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → 2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone (102293-80-1)

Conditions	Yield
With toluene-4-sulfonic acid In dichloromethane	99%
With toluene-4-sulfonic acid In dichloromethane at 20℃;	84%
In dichloromethane at 20℃; for 10h;	82%

2-Methoxypropene (116-11-0) + N-tert-butylbenzylamine (3378-72-1) + 2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → C23H29NO3

Conditions	Yield
Stage #1: 2-Methoxypropene; 2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone With toluene-4-sulfonic acid In acetone at 0 - 5℃; for 1h; Stage #2: N-tert-butylbenzylamine In acetone at 55℃; for 22h;	80%

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → (R)-(-)-salmeterol

Conditions

Yield

Multi-step reaction with 5 steps 1.1: resin-SO3H / CH2Cl2 2.1: resin-N(iPr)2 / tetrahydrofuran 3.1: CaCl2 / methanol / 0.17 h / 0 °C 3.2: 76 percent / resin-NMe3(1+)*BH4(1-) / methanol / 2 h / 0 - 20 °C 4.1: (polystyrylmethyl)trimethylammonium cyanoborohydride; AcOH / CH2Cl2 4.2: 98 percent / resin-NMe3(1+)*NaCO3(1-) / CH2Cl2 5.1: H2 / Pd(OH)2/C / ethyl acetate / 2 h 5.2: 87 percent / SCX-2 View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → (1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanone (380414-67-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: resin-SO3H / CH2Cl2 2: resin-N(iPr)2 / tetrahydrofuran View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → (1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanol (380414-68-6)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: resin-SO3H / CH2Cl2 2.1: resin-N(iPr)2 / tetrahydrofuran 3.1: CaCl2 / methanol / 0.17 h / 0 °C 3.2: 76 percent / resin-NMe3(1+)*BH4(1-) / methanol / 2 h / 0 - 20 °C View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → (1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol (380414-69-7)

Conditions	Yield
Multi-step reaction with 4 steps 1.1: resin-SO3H / CH2Cl2 2.1: resin-N(iPr)2 / tetrahydrofuran 3.1: CaCl2 / methanol / 0.17 h / 0 °C 3.2: 76 percent / resin-NMe3(1+)*BH4(1-) / methanol / 2 h / 0 - 20 °C 4.1: (polystyrylmethyl)trimethylammonium cyanoborohydride; AcOH / CH2Cl2 4.2: 98 percent / resin-NMe3(1+)*NaCO3(1-) / CH2Cl2 View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → 2-{bis-[6-(4-phenyl-butoxy)-hexyl]-amino}-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-ethanol

Conditions	Yield
Multi-step reaction with 4 steps 1.1: resin-SO3H / CH2Cl2 2.1: resin-N(iPr)2 / tetrahydrofuran 3.1: CaCl2 / methanol / 0.17 h / 0 °C 3.2: 76 percent / resin-NMe3(1+)*BH4(1-) / methanol / 2 h / 0 - 20 °C 4.1: H2 / Pd(OH)2/C / ethyl acetate View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → (1S)-2-amino-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol (384340-07-2)

Conditions	Yield
Multi-step reaction with 4 steps 1: 100 percent / TsOH*H2O / CH2Cl2 / 0.67 h / 0 °C 2: 95 percent / NaN3 / dimethylformamide / 2 h / 20 °C 3: 94 percent / Pichia angusta / acetonitrile / 48 h / 28 °C 4: 86 percent / H2 / Pd/C / ethanol / 3 h View Scheme
Multi-step reaction with 4 steps 1: 100 percent / TsOH*H2O / CH2Cl2 / 0.67 h / 0 °C 2: 95 percent / NaN3 / dimethylformamide / 2 h / 20 °C 3: Mucor racemosus / 42 h 4: 86 percent / H2 / Pd/C / ethanol / 3 h View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → 2-azido-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone (384340-05-0)

Conditions	Yield
Multi-step reaction with 2 steps 1: 100 percent / TsOH*H2O / CH2Cl2 / 0.67 h / 0 °C 2: 95 percent / NaN3 / dimethylformamide / 2 h / 20 °C View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → (1S)-2-azido-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol (384340-06-1)

Conditions	Yield
Multi-step reaction with 3 steps 1: 100 percent / TsOH*H2O / CH2Cl2 / 0.67 h / 0 °C 2: 95 percent / NaN3 / dimethylformamide / 2 h / 20 °C 3: 94 percent / Pichia angusta / acetonitrile / 48 h / 28 °C View Scheme
Multi-step reaction with 3 steps 1: 100 percent / TsOH*H2O / CH2Cl2 / 0.67 h / 0 °C 2: 95 percent / NaN3 / dimethylformamide / 2 h / 20 °C 3: Mucor racemosus / 42 h View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → (1R)-2-AZIDO-1-(2,2-DIMETHYL-4H-1,3-BENZODIOXIN-6-YL)ETHANOL (384340-09-4)

Conditions	Yield
Multi-step reaction with 3 steps 1: 100 percent / TsOH*H2O / CH2Cl2 / 0.67 h / 0 °C 2: 95 percent / NaN3 / dimethylformamide / 2 h / 20 °C 3: Mucor racemosus / 42 h View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → (1S)-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-{[6-(4-phenylbutoxy)hexyl]amino}ethanol (384340-08-3)

Conditions	Yield
Multi-step reaction with 5 steps 1: 100 percent / TsOH*H2O / CH2Cl2 / 0.67 h / 0 °C 2: 95 percent / NaN3 / dimethylformamide / 2 h / 20 °C 3: 94 percent / Pichia angusta / acetonitrile / 48 h / 28 °C 4: 86 percent / H2 / Pd/C / ethanol / 3 h 5: 70 percent / dimethylformamide / 67 h / 20 °C View Scheme
Multi-step reaction with 5 steps 1: 100 percent / TsOH*H2O / CH2Cl2 / 0.67 h / 0 °C 2: 95 percent / NaN3 / dimethylformamide / 2 h / 20 °C 3: Mucor racemosus / 42 h 4: 86 percent / H2 / Pd/C / ethanol / 3 h 5: 70 percent / dimethylformamide / 67 h / 20 °C View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → (S)-salmeterol acetate

Conditions	Yield
Multi-step reaction with 6 steps 1: 100 percent / TsOH*H2O / CH2Cl2 / 0.67 h / 0 °C 2: 95 percent / NaN3 / dimethylformamide / 2 h / 20 °C 3: 94 percent / Pichia angusta / acetonitrile / 48 h / 28 °C 4: 86 percent / H2 / Pd/C / ethanol / 3 h 5: 70 percent / dimethylformamide / 67 h / 20 °C 6: 100 percent / H2O / 0.5 h / 71 °C View Scheme
Multi-step reaction with 6 steps 1: 100 percent / TsOH*H2O / CH2Cl2 / 0.67 h / 0 °C 2: 95 percent / NaN3 / dimethylformamide / 2 h / 20 °C 3: Mucor racemosus / 42 h 4: 86 percent / H2 / Pd/C / ethanol / 3 h 5: 70 percent / dimethylformamide / 67 h / 20 °C 6: 100 percent / H2O / 0.5 h / 71 °C View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → 2-{bis-[6-(4-phenyl-butoxy)-hexyl]-amino}-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-ethanol

Conditions	Yield
Multi-step reaction with 5 steps 1: 100 percent / TsOH*H2O / CH2Cl2 / 0.67 h / 0 °C 2: 95 percent / NaN3 / dimethylformamide / 2 h / 20 °C 3: 94 percent / Pichia angusta / acetonitrile / 48 h / 28 °C 4: 86 percent / H2 / Pd/C / ethanol / 3 h 5: dimethylformamide / 67 h / 20 °C View Scheme
Multi-step reaction with 5 steps 1: 100 percent / TsOH*H2O / CH2Cl2 / 0.67 h / 0 °C 2: 95 percent / NaN3 / dimethylformamide / 2 h / 20 °C 3: Mucor racemosus / 42 h 4: 86 percent / H2 / Pd/C / ethanol / 3 h 5: dimethylformamide / 67 h / 20 °C View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → 3-(3-(2-(tert-butyldimethylsilyloxy)-2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethylamino)propoxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide (1424337-27-8)

Conditions	Yield
Multi-step reaction with 4 steps 1: dichloromethane / 10 h / 20 °C 2: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C 3: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C 4: triethylamine / N,N-dimethyl-formamide / 24 h / 65 °C View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → 3-(4-(2-(tert-butyldimethylsilyloxy)-2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethylamino)butoxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide (1424337-28-9)

Conditions	Yield
Multi-step reaction with 4 steps 1: dichloromethane / 10 h / 20 °C 2: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C 3: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C 4: triethylamine / N,N-dimethyl-formamide / 24 h / 65 °C View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → 3-(5-(2-(tert-butyldimethylsilyloxy)-2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethylamino)pentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide (1424337-29-0)

Conditions	Yield
Multi-step reaction with 4 steps 1: dichloromethane / 10 h / 20 °C 2: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C 3: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C 4: triethylamine / N,N-dimethyl-formamide / 24 h / 65 °C View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → 3-(6-(2-(tert-butyldimethylsilyloxy)-2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethylamino)hexyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide (1424337-30-3)

Conditions	Yield
Multi-step reaction with 4 steps 1: dichloromethane / 10 h / 20 °C 2: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C 3: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C 4: triethylamine / N,N-dimethyl-formamide / 24 h / 65 °C View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → C28H31Cl2N3O6

Conditions	Yield
Multi-step reaction with 5 steps 1: dichloromethane / 10 h / 20 °C 2: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C 3: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C 4: triethylamine / N,N-dimethyl-formamide / 24 h / 65 °C 5: ammonium fluoride / water; ethanol / 48 h / 45 °C View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → C29H33Cl2N3O6

Conditions	Yield
Multi-step reaction with 5 steps 1: dichloromethane / 10 h / 20 °C 2: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C 3: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C 4: triethylamine / N,N-dimethyl-formamide / 24 h / 65 °C 5: ammonium fluoride / water; ethanol / 48 h / 45 °C View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → C30H35Cl2N3O6

Conditions	Yield
Multi-step reaction with 5 steps 1: dichloromethane / 10 h / 20 °C 2: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C 3: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C 4: triethylamine / N,N-dimethyl-formamide / 24 h / 65 °C 5: ammonium fluoride / water; ethanol / 48 h / 45 °C View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → C31H37Cl2N3O6

Conditions	Yield
Multi-step reaction with 5 steps 1: dichloromethane / 10 h / 20 °C 2: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C 3: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C 4: triethylamine / N,N-dimethyl-formamide / 24 h / 65 °C 5: ammonium fluoride / water; ethanol / 48 h / 45 °C View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → C25H27Cl2N3O6 (1424337-09-6)

Conditions	Yield
Multi-step reaction with 6 steps 1: dichloromethane / 10 h / 20 °C 2: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C 3: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C 4: triethylamine / N,N-dimethyl-formamide / 24 h / 65 °C 5: ammonium fluoride / water; ethanol / 48 h / 45 °C 6: hydrogenchloride / water; ethanol / 12 h / 20 °C View Scheme

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone (62932-94-9) → C26H29Cl2N3O6 (1424337-10-9)

Conditions	Yield
Multi-step reaction with 6 steps 1: dichloromethane / 10 h / 20 °C 2: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C 3: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C 4: triethylamine / N,N-dimethyl-formamide / 24 h / 65 °C 5: ammonium fluoride / water; ethanol / 48 h / 45 °C 6: hydrogenchloride / water; ethanol / 12 h / 20 °C View Scheme

Upstream product

• 24085-07-2 3'-acetoxymethyl-4'-acetoxy-2-bromoacetophenone 
• 24085-06-1 4'-acetoxy-3'-(acetoxymethyl)acetophenone 
• 115787-50-3 5-(2-bromoacetyl)-2-hydroxybenzaldehyde 
• 90-02-8 salicylaldehyde 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 102293-80-1 2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone 
• 54208-72-9 2-(tert-butylamino)-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxan-6-yl)ethanol 
• 238762-33-9 C₁₆H₂₅NO₃*C₂₀H₁₈O₈ 
• 384340-08-3 (1S)-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-{[6-(4-phenylbutoxy)hexyl]amino}ethanol 
• 380414-69-7 (1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol 
• 380414-68-6 (1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanol 
• 380414-67-5 (1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanone 
• 135271-47-5 (R)-(-)-salmeterol 

Relevant articles and documents

Synthesis method of salbutamol sulfate intermediate

The invention discloses a synthesis method of a salbutamol sulfate intermediate, which comprises the following steps: by taking salicylaldehyde as a raw material, carrying out three-step reaction of Friedel-Crafts acylation, reduction, propylidene protection and N alkylation, and obtaining the target product salbutamol intermediate with the reaction yield of more than 60% in each step. The synthesis method of the salbutamol sulfate intermediate has the advantages of few reaction steps, simple post-treatment and high product purity.

Levalbuterol intermediate and synthetic method of levalbuterol hydrochloride

The invention provides a levalbuterol intermediate and a levalbuterol hydrochloride synthesis method, and relates to a levalbuterol intermediate and a method for preparing levalbuterol hydrochloride from the intermediate. The method comprises steps as follows: 2-halogenate-1-(2,2-dimelthyl-4-hydrogen-benzo [d][1,3] dioxane)-butanone and organic amine have a Hoffman alkylation reaction to prepare a compound in the formula 2, the structural formula of the compound is shown in the specification, and the compound in the formula 2 is subjected to a reduction reaction, optically pure organic acid resolution and deprotection by hydrochloric acid to obtain levalbuterol hydrochloride. The method does not need processes of protection or deprotection and the like of hydroxyl groups on a benzene ring, protection, deprotection and purification processes are reduced, the synthesis route is short, operation is simple, meanwhile, borane-thioether does not need to be used as a reduction agent, and safety and environmental protection are realized.

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