24086-18-8

Usage

Uses

Used in Pharmaceutical Industry:
5-Iodo-4-methyl-1H-pyrazole is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its primary application is in the preparation of (acylaryl)imidazoles, which serve as lipid synthesis modulators. These modulators can potentially be used in the treatment of lipid metabolism disorders and related health conditions.
Additionally, 5-Iodo-4-methyl-1H-pyrazole is utilized in the synthesis of aminopyridines, which act as GPBAR1 agonists. These agonists are beneficial in the treatment of type II diabetes, as they help regulate glucose homeostasis and improve insulin sensitivity in patients.
Used in Chemical Industry:
In the chemical industry, 5-Iodo-4-methyl-1H-pyrazole may be employed as a building block for the development of new compounds with potential applications in various fields, such as materials science, agrochemistry, and environmental science. Its unique structural features make it a valuable component in the design and synthesis of novel molecules with specific properties and functions.

Upstream product

• 7554-65-6 4-methyl-1H-pyrazole 

Downstream Products

• 1164166-15-7 3-iodo-4-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole 
• 38858-90-1 4-methyl-3-nitro-1H-pyrazole 
• 1395443-04-5 3-iodo-1,4-dimethyl-1H-pyrazole 

Relevant academic research and scientific papers

NITROGEN-CONTAINING FUSED BICYCLIC COMPOUNDS AND THEIR USE AS UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 1 (USP1) INHIBITORS

The present disclosure provides compounds having Formula (I): (I) and the pharmaceutically acceptable salts and solvates thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R6, R6', R7, and R7' are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to inhibit a USP1 protein and/or to treat a disorder responsive to the inhibition of USP1 proteins and USP1 activity. Compounds of the present disclosure are especially useful for treating cancer.

N-SUBSTITUTED-DIOXOCYCLOBUTENYLAMINO-3-HYDROXY-PICOLINAMIDES USEFUL AS CCR6 INHIBITORS

The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

AhR MODULATORS

Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: (I) wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

PYRAZOLE DERIVATIVES

Provided herein are compounds of the formula I: as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment or prevention of mGluR5 mediated disorders, such as acute and/or chronic neurological disorders, cognitive disorders and memory deficits, as well as acute and chronic pain.

HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS AND COMBINATIONS THEREOF

Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS

Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

HERBICIDAL PYRIDAZINONE DERIVATIVES

Disclosed are compounds of Formula (1), N-oxides, and salts thereof, wherein W1 is O or S, and R1, R2, R3, G and J are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.