38858-90-1

Usage

Uses

4-Methyl-3-nitropyrazole is used in the synthesis of 4-(N-azolyl)-3,5-dinitropyrazoles.

InChI:InChI=1S/C4H5N3O2/c1-3-2-5-6-4(3)7(8)9/h2H,1H3,(H,5,6)

Upstream product

• 7554-65-6 4-methyl-1H-pyrazole 
• 24086-18-8 3-iodo-4-methyl-1H-pyrazole 

Downstream Products

• 1246855-83-3 1-(3,5-dinitrophenyl)-4-methyl-3-nitropyrazole 
• 26956-09-2 1,4-dimethyl-3-nitropyrazole 

Relevant academic research and scientific papers

INHIBITORS OF NECROPTOSIS

This invention relates to compounds of Formula (I) and salts, solvates, prodrugs, tautomers, N-oxides, stereoisomers, polymorphs and physiologically functional derivatives thereof. Also disclosed are methods of use of Formula (I), including in the inhibition of necroptosis and treatment of associated diseases, conditions and/or disorders.

HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF

The present disclosure relates to heterocycle substituted amino-pyridine compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Faujasite catalyzed nitrodeiodination of iodopyrazoles

Nitrodeiodination of iodopyrazoles using nitric acid/Faujasite has been investigated. The present procedure is simple, rapid and convenient and requires no sulfuric acid or oleum and may be applied for the synthesis of several nitropyrazoles in good yield

A simple and environmentally benign nitration of pyrazoles by impregnated bismuth nitrate

We report herein a facile, rapid, and environmentally friendly synthesis of nitropyrazoles in good yields using silica-bismuth nitrate and silica-sulfuric acid-bismuth nitrate at room temperature for the first time. The relatively non-toxic nature, ease o

Silica-sulfuric acid catalyzed nitrodeiodination of iodopyrazoles

We report here the synthesis of nitropyrazoles in good to excellent yields from iodopyrazoles over silica-sulfuric acid catalyst for the first time. The present procedure require less acid, offers a simplified workup procedure, and may be applied for the

Facile and environmentally friendly synthesis of nitropyrazoles using montmorillonite K-10 impregnated with bismuth nitrate

Nitropyrazoles in higher yields were synthesized using montmorillonite K-10 impregnated with bismuth nitrate and the present procedure may be applied for the nitration of a wide variety of azoles in the drug and pharmaceutical industries.

Nitropyrazoles 17.* Synthesis of 1-(3,5-dinitrophenyl)-4-methyl-3,5- dinitropyrazole and the study of its chemical transformations

A new one-step method for the synthesis of 4-methyl-3(5)-nitropyrazole by nitration of 4-methylpyrazole is developed. Arylation of 4-methyl-3(5)- nitropyrazole with 1,3,5-trinitrobenzene gives 1-(3,5-dinitrophenyl)-4-methyl-3- nitropyrazole, nitration of