24090-92-4Relevant academic research and scientific papers
Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs
Chapman, Eli,Chitre, Siddhi,Hoang, Quyen Q.,Howe, Chris,Johnson, Steven M.,Park, Yangshin,Ray, Anne-Marie,Sivinski, Jared,Stevens, Mckayla,Washburn, Alex
, (2020/09/15)
In two previous studies, we identified compound 1 as a moderate GroEL/ES inhibitor with weak to moderate antibacterial activity against Gram-positive and Gram-negative bacteria including Bacillus subtilis, methicillin-resistant Staphylococcus aureus, Kleb
Iron(III)/TEMPO-Catalyzed Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles by Oxidative Cyclization under Mild Conditions
Zhang, Guofu,Yu, Yidong,Zhao, Yiyong,Xie, Xiaoqiang,Ding, Chengrong
, p. 1373 - 1377 (2017/06/27)
A simple and efficient cationic Fe(III)/TEMPO-catalyzed oxidative cyclization of aroyl hydrazones has been developed for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives. The reaction offers a broad scope, good functional-group tolerance, and high yields under mild conditions in the presence of O 2.
Regioselective cyclometallation with some platinum group metal ions
Balavardhana Rao,Pal, Samudranil
, p. 58 - 66 (2014/05/20)
Reactions of [Rh(PPh3)3Cl], [Ir(PPh3) 3Cl], Li2[PdCl4] and K2[PtCl 4] with the corresponding 4-R-Nê(arylidene)benzohydrazides (H2Ln; n = 1 and 2 for arylidene = 1-pyrenylidene and R = H and Cl, respectively and n = 3 for arylidene = 1-naphthylidene and R = H) in presence of NaOAc·3H2O in methanol/toluene provide the complexes with general formula trans-[Rh(Ln)(PPh3) 2H] (1 and 2), trans-[Ir(Ln)(PPh3) 2H] (3 and 4), [Pd(HLn)Cl] (5) and [Pt(HLn)Cl] (6), respectively. Reactions of 5 and 6 with PPh3 in acetone produce the complexes [Pd(Ln)(PPh3)] (7) and [Pt(L n)(PPh3)] (8), respectively. All the complexes have been characterized with the help of microanalysis (CHN), spectroscopic (infrared, NMR, electronic and emission) and cyclic voltammetric measurements. Molecular structures of 1-5 and 8 have been confirmed with single crystal X-ray crystallography. In 5 and 6, (HL1)- acts as a monobasic CNO-donor ligand, whereas in each of 1-4, 7 and 8, the (Ln) 2- acts as a dibasic CNO-donor ligand. In 1, 2, 5 and 7, metallation at the peri position of the 1-pyrenyl moiety of the pincer like ligand leads to the formation of 6,5-membered fused chelate rings, whereas in 3, 4, 6 and 8 metallation takes place at ortho position of the 1-pyrenyl/1-naphthalenyl moiety of the ligand with the formation of 5,5-membered fused chelate rings.
Efficient oxidative cyclization of N -acylhydrazones for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles using t-BuOI under neutral conditions
Gao, Peng,Wei, Yunyang
, p. 113 - 119 (2013/05/23)
An efficient procedure for the oxidative cyclization of N -acylhydrazones was developed utilizing tert-butyl hypoiodite (t-BuOI), which is generated in situ from t -BuOCl and NaI. A variety of 2,5-disubstituted 1,3,4-oxadiazoles were synthesized in high yields within short reaction time. The method is also suitable for cyclization of N -acylhydrazones derived from heterocyclic aldehydes and aliphatic aldehydes. Mild reaction conditions and simple workup operations make the procedure a good alternative for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles.
Regioselective cyclometallation of 4-R-1-naphthaldehyde benzoylhydrazones: Palladium(II) complexes with CNO pincer like ligands
Rao, A.R. Balavardhana,Pal, Samudranil
, p. 67 - 72 (2013/05/21)
Reactions of Li2PdCl4, 4-R-1-naphthaldehyde benzoylhydrazones (H2Ln; n = 1 and 2 for R = H and OMe, respectively) and NaOAc·3H2O in 1:1:1 mole ratio in methanol provide the cyclopalladated complexes w
I2-mediated oxidative C-O bond formation for the synthesis of 1,3,4-oxadiazoles from aldehydes and hydrazides
Yu, Wenquan,Huang, Gang,Zhang, Yueteng,Liu, Hongxu,Dong, Lihong,Yu, Xuejun,Li, Yujiang,Chang, Junbiao
, p. 10337 - 10343 (2013/11/06)
A practical and transition-metal-free oxidative cyclization of acylhydrazones into 1,3,4-oxadiazoles has been developed by employing stoichiometric molecular iodine in the presence of potassium carbonate. The conditions of this cyclization reaction also work well with crude acylhydrazone substrates obtained from the condensation of aldehydes and hydrazides. A series of symmetrical and asymmetrical 2,5-disubstituted (aryl, alkyl, and/or vinyl) 1,3,4-oxadiazoles can be conveniently generated in an efficient and scalable fashion.
