24096-52-4

Usage

Uses

Used in Organic Synthesis:
1-(3,5-DICHLORO-PHENYL)-PYRROLE-2,5-DIONE is used as a key intermediate in organic synthesis for the creation of various chemical compounds. Its unique structure allows for the formation of new bonds and the synthesis of complex molecules, making it a versatile component in the development of novel organic compounds.
Used in Material Science:
In the field of material science, 1-(3,5-DICHLORO-PHENYL)-PYRROLE-2,5-DIONE is utilized as a component in the design and synthesis of new materials. Its properties can contribute to the development of materials with specific characteristics, such as improved stability, reactivity, or selectivity, depending on the application.
Used in Pharmaceutical Research:
1-(3,5-DICHLORO-PHENYL)-PYRROLE-2,5-DIONE is used as a potential candidate in pharmaceutical research for its possible biological activity. Its unique structure may offer new avenues for drug discovery, particularly in the development of compounds with therapeutic potential.
Used in the Development of New Compounds:
Due to its diverse functional groups and structural features, 1-(3,5-DICHLORO-PHENYL)-PYRROLE-2,5-DIONE is used as a building block in the synthesis of new compounds with a wide range of applications. Its versatility allows for the exploration of its potential in various industries, including chemical manufacturing, pharmaceuticals, and materials development.

InChI:InChI=1/C10H5Cl2NO2/c11-6-3-7(12)5-8(4-6)13-9(14)1-2-10(13)15/h1-5H

Upstream product

• 617-48-1 malic acid 
• 626-43-7 3,5-Dichloroaniline 
• 108-31-6 maleic anhydride 
• 55198-61-3 (Z)-4-((3,5-dichlorophenyl)amino)-4-oxobut-2-enoic acid 

Downstream Products

• 144835-83-6 3-phenyl-5-(3,5-dichlorophenyl)-3a,4,6,6a-tetrahydropyrrolo<3,4-d>isoxazole 
• 144835-87-0 (3aR,6aS)-5-(3,5-Dichloro-phenyl)-3-(3-nitro-phenyl)-3a,6a-dihydro-pyrrolo[3,4-d]isoxazole-4,6-dione 
• 144835-99-4 (3aR,6aS)-3-(4-Bromo-phenyl)-5-(3,5-dichloro-phenyl)-3a,6a-dihydro-pyrrolo[3,4-d]isoxazole-4,6-dione 
• 144835-92-7 (3aR,6aS)-3-(3-Chloro-phenyl)-5-(3,5-dichloro-phenyl)-3a,6a-dihydro-pyrrolo[3,4-d]isoxazole-4,6-dione 
• 144835-94-9 (3aR,6aS)-3-(2,4-Dichloro-phenyl)-5-(3,5-dichloro-phenyl)-3a,6a-dihydro-pyrrolo[3,4-d]isoxazole-4,6-dione 
• 144835-86-9 (3aS,6aR)-5-(3,5-Dichloro-phenyl)-3-(2-nitro-phenyl)-3a,6a-dihydro-pyrrolo[3,4-d]isoxazole-4,6-dione 
• 144835-96-1 (3aS,6aR)-3-(3,4-Dichloro-phenyl)-5-(3,5-dichloro-phenyl)-3a,6a-dihydro-pyrrolo[3,4-d]isoxazole-4,6-dione 
• 117954-68-4 N-(3,5-dichlorophenyl)-2-cysteinylsuccimide methyl ester hydrochloride 
• 144835-90-5 (3aR,6aS)-5-(3,5-Dichloro-phenyl)-3-(4-fluoro-phenyl)-3a,6a-dihydro-pyrrolo[3,4-d]isoxazole-4,6-dione 
• 144835-91-6 (3aR,6aS)-3-(2-Chloro-phenyl)-5-(3,5-dichloro-phenyl)-3a,6a-dihydro-pyrrolo[3,4-d]isoxazole-4,6-dione 
• 144835-89-2 (3aR,6aS)-5-(3,5-Dichloro-phenyl)-3-(2-fluoro-phenyl)-3a,6a-dihydro-pyrrolo[3,4-d]isoxazole-4,6-dione 
• 144835-97-2 (3aR,6aS)-3-(2-Bromo-phenyl)-5-(3,5-dichloro-phenyl)-3a,6a-dihydro-pyrrolo[3,4-d]isoxazole-4,6-dione 
• 144835-98-3 (3aR,6aS)-3-(3-Bromo-phenyl)-5-(3,5-dichloro-phenyl)-3a,6a-dihydro-pyrrolo[3,4-d]isoxazole-4,6-dione 
• 144835-48-3 (3aS,6aR)-5-(3,5-Dichloro-phenyl)-3-(2-trifluoromethyl-phenyl)-3a,6a-dihydro-pyrrolo[3,4-d]isoxazole-4,6-dione 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS

The invention relates to a compound of Formula (I) or (IA) compositions comprising compounds of Formula (I) or (IA), and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula (I) or (IA) to a patient in need thereof:

Potent Nematicidal Activity of Maleimide Derivatives on Meloidogyne incognita

Different maleimide derivatives were synthesized and assayed for their in vitro activity on the soil inhabiting, plant-parasitic nematode Meloidogyne incognita, also known as root-knot nematode. The compounds maleimide, N-ethylmaleimide, N-isopropylmaleimide, and N-isobutylmaleimide showed the strongest nematicidal activity on the second stage juveniles of the root-knot nematode with EC50/72h values of 2.6 ± 1.3, 5.1 ± 3.4, 16.2 ± 5.4, and 19.0 ± 9.0 mg/L, respectively. We also determined the nematicidal activity of copper sulfate, finding an EC50 value of 48.6 ± 29.8 mg/L. When maleimide at 1 mg/L was tested in combination with copper sulfate at 50 mg/L, we observed 100% mortality of the nematodes. We performed a GC-MS metabolomics analysis after treating nematodes with maleimide at 8 mg/L for 24 h. This analysis revealed altered fatty acids and diglyceride metabolites such as oleic acid, palmitic acid, and 1-monopalmitin. Our results suggest that maleimide may be used as a new interesting building block for developing new nematicides in combination with copper salts.

SMALL MOLECULE LFA-1 INHIBITORS

The present invention relates to novel compounds which are capable of inhibiting the interaction of LFA-1 with its counter ligands.

DABCO-catalyzed [3+2] cycloaddition reactions of azomethine imines with N-aryl maleimides: Facile access to dinitrogen-fused heterocycles

DABCO-catalyzed [3+2] cycloaddition of azomethine imines with maleimides has been developed. This method could efficiently furnish dinitrogen-fused tetracyclic heterocycles in high levels of regioselectivity and with good yields.

Direct synthesis of imides from dicarboxylic acids using microwaves

1,4- and 1,5-dicarboxylic acids, when treated with amines in a domestic microwave oven, afford good yields of the corresponding imides.

Antimicrobial composition and method containing N-(3,5-dihalophenyl)-imide compounds

Novel N-(3,5-dihalophenyl)imide compounds, which exhibit a strong antimicrobial activity against microorganisms including phytopathogenic fungi, parasites of industrial products and pathogenic microorganisms, represented by the formula, STR1 wherein X and X' each represent halogens and A represents a substituted ethylene such as chloroethylene, C1 - C4 alkylthioethylene, C1 - C2 alkyl-ethylene or 1,2-di-C1 - C2 -alkyl-ethylene, a cyclopropylene such as 1,3-dimethylcyclopropylene, trimethylene, a cyclohexylene-1,2-, cyclohexenylene-1,2-, cyclohexadienylene-1,2- or o-phenylene. The N-(3,5-dihalophenyl)imide compounds can be obtained by any of methods which produce imide compounds or reaction of an N-(3,5-dihalophenyl)maleimide compound with a mercaptan, a hydrogen halide, phosphorus chloride or thionylchloride.