80827-67-4

Basic information

• Product Name: 1-(3-METHOXY-PYRIDIN-2-YL)-PIPERAZINE
• Synonyms: 1-(3-METHOXY-PYRIDIN-2-YL)-PIPERAZINE;1-(3-Methoxypyridin-2-yl)
• CAS NO: 80827-67-4
• Molecular Formula: C₁₀H₁₅N₃O
• Molecular Weight: 193.25
• Mol File: 80827-67-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 50.5-51.5 °C
• Boiling Point: 355.965°C at 760 mmHg
• Flash Point: 169.082°C
• Appearance: /
• Density: 1.105g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.536
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 11.33±0.10(Predicted)
• CAS DataBase Reference: 1-(3-METHOXY-PYRIDIN-2-YL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-METHOXY-PYRIDIN-2-YL)-PIPERAZINE(80827-67-4)
• EPA Substance Registry System: 1-(3-METHOXY-PYRIDIN-2-YL)-PIPERAZINE(80827-67-4)

Safety Data

• Hazardous Substances Data: 80827-67-4(Hazardous Substances Data)

Usage

General Description

1-(3-Methoxy-pyridin-2-yl)-piperazine is a chemical compound with a molecular structure containing a piperazine ring and a 3-methoxy-pyridin-2-yl group. It is commonly used as an intermediate in the synthesis of pharmaceutical compounds and research chemicals. The presence of the piperazine ring makes it potentially useful as a central nervous system depressant, an antagonist at various serotonin receptors, and a dopamine receptor agonist. The 3-methoxy-pyridin-2-yl group provides potential for interactions with other biological targets, making it a potentially versatile compound for medicinal chemistry research. It is important to note that this compound should only be handled and used by trained professionals in a controlled laboratory setting due to its potential hazards and restricted uses.

InChI:InChI=1/C10H15N3O/c1-14-9-3-2-4-12-10(9)13-7-5-11-6-8-13/h2-4,11H,5-8H2,1H3

Upstream product

• 1260082-69-6 4-(3-methoxypyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester 
• 24100-18-3 2-bromo-3-methoxypyridine 
• 110-85-0 piperazine 
• 17228-64-7 6-chloro-2-methoxypyridine 
• 6636-78-8 2-chloro-3-hydroxypyridine 
• 74-88-4 methyl iodide 
• 6602-32-0 2-bromo-pyridin-3-ol 

Downstream Products

• 178974-48-6 1-(8-aza-bicyclo[3.2.1]oct-8-yl)-4-[4-(3-methoxy-pyridin-2-yl)-piperazin-1-yl]-2-phenyl-butan-1-one 

Relevant articles and documents

Substituted indole compound and method and use thereof

The invention provides a new indole compound, pharmaceutically acceptable salts and medicinal preparations thereof, and a use of the new indole compound in selective inhibition of 5-hydroxytryptamine reuptake and /or excitation of a 5-HT1A receptor. The invention also relates to medicinal compositions comprising the compounds, and a method for treating the central nervous system dysfunction of mammals, especially humans by using the medicinal compositions.

Substituted piperazines

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Succinimide derivatives, and their production and use

A succinimide derivative of the formula: STR1 wherein R is a pyridyl or pyrimidinyl group substituted with at least one member selected from the group consisting of halogen, lower alkyl, lower alkoxy, cyano, benzyloxy, hydroxyl and amino, and n is an integer of 1 or 2, or a pharmaceutically acceptable acid addition salt thereof. The succinimide derivatives are useful as an anti-anxiety drugs.