263409-81-0Relevant articles and documents
HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS
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Paragraph 000221, (2015/10/05)
ABSTRACT The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
Development of a scalable synthesis of a nonbasic inhibitor of the serine protease tryptase
Dener, Jeffrey M.,O'Bryan, Colin,Yee, Robert,Shelton, Emma J.,Sperandio, David,Mahajan, Tania,Palmer, James T.,Spencer, Jeffrey R.,Tong, Zhiwei
, p. 4591 - 4595 (2007/10/03)
A chromatography-free process for the synthesis of a bis(benzimidazole)difluoromethane inhibitor of the serine protease tryptase is described. This synthesis features the introduction of the gem-difluoro moiety using the electrophilic fluorinating reagent N-fluoro-bis(phenylsulfonimide) as well as the stepwise introduction of both benzimidazole rings. A protocol for the destruction of reactive, process-related substances produced in the synthesis is also presented.
HYDROXY-TETRAHYDRO-NAPHTHALENYLUREA DERIVATIVES
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Page 43-45, (2008/06/13)
This invention relates to hydroxy-tetrahydro-naphthalenylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The hydroxy-tetrahydro-naphthalenylurea derivatives of the present invention have an excelle