24147-49-7

Usage

Uses

Used in Pharmaceutical Research:
2-(diphenylamino)thiazol-4(5H)-one is used as a building block for the synthesis of various biologically active compounds, contributing to the development of novel drugs. Its potential in anti-cancer properties has been a focal point of study, indicating its utility in the creation of therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 2-(diphenylamino)thiazol-4(5H)-one is employed as a key intermediate, facilitating the construction of complex molecular structures that are vital for the advancement of chemical research and the pharmaceutical industry.
Used in Chemical Sensors:
2-(diphenylamino)thiazol-4(5H)-one is used as a fluorescent probe for the detection of metal ions, making it an essential component in the development of sensitive and selective chemical sensors for environmental and analytical applications.
Used in Drug Discovery:
DPAZT is utilized in drug discovery as a valuable tool, with its unique structure and pharmacological properties aiding in the identification and optimization of potential drug candidates, particularly in the area of anti-cancer therapeutics.

InChI:InChI=1/C15H12N2OS/c18-14-11-19-15(16-14)17(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10H,11H2

Upstream product

• 79-04-9 chloroacetyl chloride 
• 70989-46-7 N-benzoyl-N',N'-diphenylthiourea 
• 122-39-4 diphenylamine 
• 3898-08-6 1,1-diphenylthiourea 

Downstream Products

• 296793-12-9 2-diphenylamino-5-(3-methyl-3H-benzothiazol-2-ylidene)-thiazol-4-one 
• 68-11-1 mercaptoacetic acid 
• 2786-25-6 5-[2-(5-chloro-3-methyl-3H-benzothiazol-2-ylidene)-ethylidene]-2-diphenylamino-thiazol-4-one 
• 2786-60-9 2-diphenylamino-5-(3-methyl-2,3-dihydro-benzothiazol-2-yl)-thiazol-4-one 
• 16021-43-5 2-diphenylamino-5-(1-methyl-1,4-dihydro-quinolin-4-yl)-thiazol-4-one 
• 2896-48-2 2-diphenylamino-5-(3-methyl-2,3-dihydro-benzoselenazol-2-yl)-thiazol-4-one 
• 3730-40-3 5-(1,3-dioxo-indan-2-ylmethylene)-2'-diphenylamino-3-ethyl-[2,5']bithiazolylidene-4,4'-dione 

Relevant academic research and scientific papers

Fluorescent Styryl Dyes from 4-Chloro-2-(Diphenylamino)-1, 3-Thiazole-5-Carbaldehyde - Synthesis, Optical Properties and TDDFT Computations

4-Chloro-2-(diphenylamino)-1,3-thiazole-5-carbaldehyde was reacted with an active methylene compounds, cyanomethyl benzimidazole, cyanomethyl benzothiazole, barbituric acid and Meldrum's acid under Knoevenagel conditions to give novel push-pull styryl chromophores 8a-8d. The synthesized styryl chromophores were characterized by FT-IR, Mass and 1H NMR spectral analysis. The photophysical characteristics of these styryl chromophores were evaluated. The effect of solvent polarity and viscosity on the absorption and emission properties of these chromophores was studied. The structural, molecular, electronic and photophysical parameters of the push-pull dyes were studied by using density functional theory (DFT) and time dependent density functional theory (TDDFT) computations. The ratio of the ground to the excited state dipole moment of the synthesized novel styryl dyes were calculated by Bakhshiev and Bilot-Kawski correlations.

Reaction of acyl isothiocyanates with nucleophiles: A convenient synthesis of 1,3-oxazine, pyrimidinethione and thiazole derivatives

The reaction of acetyl isothiocyanate 1 with ethyl cyanoacetate, malononitrile and/or a cyclic β-diketone afforded the corresponding 1,3-oxazines 3, 11 and thioamide 12 respectively. The heteroannulation of 3 and the synthesis of thiazole 18 is described.