88197-48-2Relevant academic research and scientific papers
Preparation method of cinepazide maleate intermediate
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Paragraph 0019; 0021, (2020/12/15)
The invention provides a preparation method of a cinepazide maleate intermediate, which comprises the following steps: reacting (E) 3, 4, 5trimethoxycinnamoyl chloride and diethanol amine used as initial raw materials under the action of alkali to generate an intermediate c (E) N, N-(2-hydroxyethyl)-3, 4, 5-trimethoxycinnamamide, chlorinating hydroxyl under the action of thionyl chloride to obtainan intermediate d (E) N, N-(2-chloroethyl)-3, 4, 5-trimethoxycinnamamide, and reacting with e alpha-aminoacetylpyrrolidine to generate cinepazide. The synthesis route has the advantages that (1) allthe raw materials are low in cost and easy to obtain on the market and (2) the process post-treatment steps are greatly simplified, the control is easy, the industrial production can be realized, andthe process cost is reduced.
Concise and efficient synthesis of cinepazide
Nagaiah,Narsaiah, A. Venkat
, p. 1227 - 1231 (2014/04/17)
An efficient synthesis of cinepazide has been carried out in four steps with an overall yield of 51%. The synthesis was started from a commercially available 3,4,5-tri-methoxy benzaldehyde. All the reactions were very clean and the isolation of products was also very easy.
