2417-14-3

Usage

General Description

1H-Indole, 7-methoxy-6-(phenylmethoxy)- is a chemical compound with the molecular formula C21H17NO2. It is an indole derivative with a methoxy group at the 7th position and a phenylmethoxy group at the 6th position. 1H-Indole, 7-methoxy-6-(phenylmethoxy)- is a key intermediate in the synthesis of various pharmaceuticals and is also used as a building block in the production of organic compounds. It has potential therapeutic applications in the treatment of various diseases and disorders, and its molecular structure makes it an important target for research and development in medicinal chemistry. Additionally, 1H-Indole, 7-methoxy-6-(phenylmethoxy)- may also have potential applications in the field of organic synthesis and material science due to its unique chemical properties and structural characteristics.

Upstream product

• 947321-82-6 4-benzyloxy-3-methoxy-2,β-dinitrostyrene 
• 2450-26-2 2-nitrovanillin 
• 2432-60-2 1-benzyloxy-2-methoxy-3-nitro-4-(2-nitro-vinyl)-benzene 
• 100-39-0 benzyl bromide 
• 2450-27-3 4-(benzyloxy)-3-methoxy-2-nitrobenzaldehyde 

Downstream Products

• 947321-83-7 C₁₈H₁₇NO₄ 
• 170489-29-9 6-benzyloxy-7-methoxyindole-3-carboxaldehyde 
• 1154527-16-8 (6-benzyloxy-7-methoxy-1H-indol-3-ylmethyl)-dimethylamine 

Relevant academic research and scientific papers

Studies on paraherquamide biosynthesis: synthesis of deuterium-labeled 7-hydroxy-pre-paraherquamide, a putative precursor of paraherquamides A, E, and F

The stereocontrolled, asymmetric synthesis of triply deuterium-labeled 7-hydroxy-pre-paraherquamide (27) was accomplished, employing a diastereoselective intramolecular SN2′ cyclization strategy. The deuterium-labeled substrate was interrogated in a precursor incorporation experiment in the paraherquamide-producing organism Penicillium fellutanum. The isolated sample of paraherquamide A revealed incorporation of one of the two geminal deuterons of the CD2-group at C-12 exclusively. The lack of signals for the second deuteron of the CD2-group at C-12 and for the CH2D-group (C-22/C-23) suggests that this substrate suffered an unexpectedly selective catabolic degradation and metabolic re-incorporation of deuterium thus casting doubt on the proposed biosynthetic intermediacy of 27. Consideration of alternative biosynthetic pathways, including oxidation of the indole C-6 position prior to hydroxylation at C-7 or oxidative spiro-contraction of pre-paraherquamide prior to construction of the dioxepin is discussed. The synthesis of 27 also provides for a concise, asymmetric stereocontrolled synthesis of an advanced intermediate that will be potentially useful in the synthesis of paraherquamides E and F.

Construction of the "left domain" of haplophytine

(Chemical Equation Presented) Left of the middle: Synthesis of the "left" structural domain (2) of haplophytine (1) features a stereoselective construction of its sterically congested carbon-carbon bond (C9′-C15) and an efficient cascade sequence involvin

Use of indole derivative for dyeing keratin materials, tinctorial compositions, new compounds and dyeing process

Process for dyeing keratin fibers by using derivatives of formula: STR1 where: R1 =H, lower alkyl or SiR11 R12 R13 ; R2 and R3, which may be identical or different, =H, alkyl, carboxyl, alkoxycarbonyl or --COOSiR11 R12 R13 ; R4 to R7, which may be identical or different, =H or an O--Z group, where Z=H, C1 -C20 alkyl, aralkyl, formyl, C2 -C20 acyl, C3 -C20 alkenyl, --SiR11 R12 R13, --P(O)(OR8)2, R8 OSO2 ; or a heterocycle which may contain a P(O)(OR8) or CR9 R10 group; with the reservation that at least two of R4 to R7 denotes OZ or form a ring, and that at least one of R4 or R7 represents OZ; R8 and R9 =H, lower alkyl; R10 =alkoxy, mono- or dialkylamino; R11, R12 and R13, which may be identical or different, are alkyl groups; or their alkali metal, alkaline-earth metal, ammonium and amine salts.