24175-34-6Relevant academic research and scientific papers
New masked δ-lithiocarbonyl compounds: Preparation and synthetic applications
Gil, Juan F.,Ramon, Diego J.,Yus, Miguel
, p. 4923 - 4938 (1993)
The reaction of 2-(4-chlorobutyl)-1,3-dioxolanes (1a-c) or 2-(4-chlorobutyl)-2-ethyl-1,3-dithiane (1d) with an excess of lithium powder and a catalytic amount of naphthalene (8 mol %) in THF at - 78°C leads to a solution of the corresponding masked lithiu
Polymer supported arene-catalysed lithiation reactions
Gomez, Cecilia,Ruiz, Sonia,Yus, Miguel
, p. 7017 - 7026 (2007/10/03)
The reaction of functionalised mono or dichlorinated materials 1a-6a with an excess of lithium and a catalytic amount of a naphthalene (P(N)) or biphenyl (P(B)) supported polymer (easily prepared by radical copolymerisation of 2-vinylnaphthalene or 4-vinylbiphenyl with vinylbenzene and divinylbenzene) in THF either in the presence or not of different electrophiles [Me3SiCl, (i)prCHO, PhCHO, Et2CO, (CH2)4CO, (CH2)5CO, (c- C3H5)2CO, (i)Pr2CO, PhCOMe, PhCH=NPh] at -78 or -50°C leads, after hydrolysis with water, to the expected functionalised products 1ca-6ck. The polymeric catalyst is quantitatively recovered and can reused several times without any loss of activity.
