2421-07-0

Basic information

• Product Name: 2-ethenyl-4-methyl-1,3-dioxolane
• Synonyms: 2-ethenyl-4-methyl-1,3-dioxolane;4-Methyl-2-vinyl-1,3-dioxolane
• CAS NO: 2421-07-0
• Molecular Formula: C₆H₁₀O₂
• Molecular Weight: 114.14
• Mol File: 2421-07-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 110.8°Cat760mmHg
• Flash Point: 5.3°C
• Appearance: /
• Density: 1.022g/cm³
• Vapor Pressure: 27.4mmHg at 25°C
• Refractive Index: 1.494
• CAS DataBase Reference: 2-ethenyl-4-methyl-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethenyl-4-methyl-1,3-dioxolane(2421-07-0)
• EPA Substance Registry System: 2-ethenyl-4-methyl-1,3-dioxolane(2421-07-0)

Safety Data

• Hazardous Substances Data: 2421-07-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H10O2/c1-3-6-7-4-5(2)8-6/h3,5-6H,1,4H2,2H3

Upstream product

• 57-55-6 propylene glycol 
• 107-02-8 acrolein 

Downstream Products

• 999-61-1 2-hydroxypropyl acrylate 
• 23936-72-3 (2a) 

Relevant articles and documents

Shell-sheddable, pH-sensitive supramolecular nanoparticles based on ortho ester-modified cyclodextrin and adamantyl PEG

We report a new type of pH-sensitive supramolecular aggregates which possess a programmable character of sequential dePEGylation and degradation. As a platform of designing and building multifunctional supramolecular nanoparticles, a family of 6-OH ortho ester-modified β-cyclodextrin (β-CD) derivatives have been synthesized via the facile reaction between β-CD and cyclic ketene acetals with different alkyl lengths. These asymmetric acid-labile β-CD derivatives formed amphiphilic supramolecules with adamantane-modified PEG through host-guest interaction in polar solvents such as ethanol. The supramolecules can self-assemble in water to form acid-labile supramolecular aggregates. The results of TEM and light scattering measurements demonstrate that the size and morphology of the aggregates are influenced by the alkyl or PEG length and the host-guest feed ratio. By carefully balancing the alkyl and PEG lengths and adjusting the host-guest ratio, well-dispersed vesicles (50-100 nm) or sphere-like nanoparticles (200-500 nm) were obtained. Zeta potential measurements reveal that these supramolecular aggregates are capable of being surface-functionalized via dynamic host-guest interaction. The supramolecular aggregates were stable at pH 8.4 for at least 12 h as proven by the 1H NMR and LLS measurements. However, rapid dePEGylation occurred at pH 7.4 due to the hydrolysis of the ortho ester linkages locating at the interface, which resulted in aggregation of the dePEGylated hydrophobic inner cores. Upon further decreasing the pH to 6.4, the hydrophobic cores were further degraded due to the acid-accelerated hydrolysis of the ortho esters. The incubation stability of the acid-labile supramolecular aggregates in neutral buffer could be improved by incorporating hydrophobic poly(ε-caprolactone) into the core of the aggregates.