2424-59-1 Usage
General Description
Cyclohexyl hydrogen maleate is a chemical compound with the molecular formula C7H10O4. It is a maleic acid derivative and belongs to the class of cyclic organic compounds known as cycloalkenes. cyclohexyl hydrogen maleate is used in the production of various polymer materials and as a reagent in organic synthesis. It has applications in the manufacturing of resins, adhesives, and coatings. Cyclohexyl hydrogen maleate is also used in the development of pharmaceuticals and as an intermediate in the production of other chemicals. It is important to handle this compound with care, as it can irritate the skin and eyes and may cause respiratory irritation if inhaled. Additionally, it may have harmful effects on aquatic organisms if released into the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 2424-59-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,2 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2424-59:
(6*2)+(5*4)+(4*2)+(3*4)+(2*5)+(1*9)=71
71 % 10 = 1
So 2424-59-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H14O4/c11-9(12)6-7-10(13)14-8-4-2-1-3-5-8/h6-8H,1-5H2,(H,11,12)/b7-6-
2424-59-1Relevant articles and documents
Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A)
Van Veldhoven,Blad,Artsen,Klopman,Wolfram,Abdelkadir,Lane,Brussee,Ijzerman
supporting information; experimental part, p. 2736 - 2739 (2011/06/20)
Nicotinic acid (niacin) has been used for decades as an antidyslipidemic drug in man. Its main target is the hydroxy-carboxylic acid receptor HCA2 (GPR109A), a G protein-coupled receptor. Other acids and esters such as methyl fumarate also interact with the receptor, which constituted the basis for the current study. We synthesized a novel series of substituted propenoic acids, such as fumaric acid esters, fumaric acid amides and cinnamic acid derivatives, and determined their affinities for the HCA2 receptor. We observed a rather restricted binding pocket on the receptor with trans-cinnamic acid being the largest planar ligand in our series with appreciable affinity for the receptor. Molecular modeling and analysis of the structure-activity relationships in the series suggest a planar trans-propenoic acid pharmacophore with a maximum length of 8 ? and out-of-plane orientation of the larger substituents.
